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Apoc4 apolipoprotein C-IV [ Mus musculus (house mouse) ]

Gene ID: 11425, updated on 26-Sep-2022

Summary

Official Symbol
Apoc4provided by MGI
Official Full Name
apolipoprotein C-IVprovided by MGI
Primary source
MGI:MGI:87878
See related
Ensembl:ENSMUSG00000074336 AllianceGenome:MGI:87878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acl; apo-CIV; apoC-IV
Summary
Predicted to be involved in positive regulation of sequestering of triglyceride and triglyceride homeostasis. Predicted to act upstream of or within lipid transport. Part of very-low-density lipoprotein particle. Is expressed in liver. Orthologous to human APOC4 (apolipoprotein C4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 1196.5) and liver E18 (RPKM 452.1) See more
Orthologs
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Genomic context

See Apoc4 in Genome Data Viewer
Location:
7 A3; 7 9.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19412009..19415385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19678084..19681460, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cleft lip and palate associated transmembrane protein 1 Neighboring gene apolipoprotein C2 like Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein E

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

General gene information

Readthrough Apoc2l

Readthrough gene: Apoc2l, Included gene: Apoc2

Homology

Clone Names

  • MGC117889

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apolipoprotein C-IV
Names
apolipoprotein C2-linked
apolipoprotein C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007385.3NP_031411.1  apolipoprotein C-IV precursor

    See identical proteins and their annotated locations for NP_031411.1

    Status: VALIDATED

    Source sequence(s)
    AC149282, BB872041, BC100593
    Consensus CDS
    CCDS20910.1
    UniProtKB/Swiss-Prot
    Q61268
    Related
    ENSMUSP00000003071.9, ENSMUST00000003071.10
    Conserved Domains (1) summary
    pfam15119
    Location:28121
    APOC4; Apolipoprotein C4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19412009..19415385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)