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Trpv6 transient receptor potential cation channel, subfamily V, member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114246, updated on 12-Jan-2022

Summary

Official Symbol
Trpv6provided by RGD
Official Full Name
transient receptor potential cation channel, subfamily V, member 6provided by RGD
Primary source
RGD:69335
See related
Ensembl:ENSRNOG00000014714
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CaT1; Ecac2; Otrpc3
Summary
Enables calcium channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and protein homotetramerization. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 105.9), Uterus (RPKM 48.0) and 4 other tissues See more
Orthologs
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Genomic context

See Trpv6 in Genome Data Viewer
Location:
4q23
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70507347..70523013, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70918631..70934291, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene Eph receptor B6 Neighboring gene transient receptor potential cation channel, subfamily V, member 5 Neighboring gene LLLL and CFNLAS motif containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium activated cation channel activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in parathyroid hormone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within parathyroid hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IC
Inferred by Curator
more info
PubMed 
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 6
Names
calcium transport protein 1
epithelial apical membrane calcium transporter/channel CaT1
epithelial calcium channel 2
osmosensitive transient receptor potential channel 3
transient receptor potential cation channel, subfamily 5, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053686.2NP_446138.2  transient receptor potential cation channel subfamily V member 6

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000141
    Related
    ENSRNOP00000020616.3, ENSRNOT00000020616.4
    Conserved Domains (2) summary
    sd00045
    Location:116147
    ANK; ANK repeat [structural motif]
    cd22192
    Location:29636
    TRPV5-6; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    70507347..70523013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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