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Mtnr1a melatonin receptor 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 114211, updated on 4-Jun-2020

Summary

Official Symbol
Mtnr1aprovided by RGD
Official Full Name
melatonin receptor 1Aprovided by RGD
Primary source
RGD:620797
See related
Ensembl:ENSRNOG00000028744
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
G-protein coupled receptor for melatonin; involved in circardian rhythm and reproductive function [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 4.2), Adrenal (RPKM 1.1) and 1 other tissue See more
Orthologs

Genomic context

See Mtnr1a in Genome Data Viewer
Location:
16q11
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50339358..50358809, complement)
106 current Rn_Celera (GCF_000002265.2) 16 AC_000084.1 (45133125..45152577, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (50060173..50079905, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S26-like Neighboring gene coagulation factor XI Neighboring gene FAT atypical cadherin 1 Neighboring gene aldolase A, fructose-bisphosphate pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone binding IEA
Inferred from Electronic Annotation
more info
 
hormone binding ISO
Inferred from Sequence Orthology
more info
 
melatonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
melatonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
organic cyclic compound binding IEA
Inferred from Electronic Annotation
more info
 
organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
camera-type eye development IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
melatonin receptor type 1A
Names
mel-1A-R
mel1a melatonin receptor
mel1a receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053676.2NP_446128.1  melatonin receptor type 1A

    See identical proteins and their annotated locations for NP_446128.1

    Status: PROVISIONAL

    Source sequence(s)
    AB377274
    UniProtKB/TrEMBL
    B7X945
    Related
    ENSRNOP00000034328.3, ENSRNOT00000039331.3
    Conserved Domains (2) summary
    pfam00001
    Location:47298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:38160
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    50339358..50358809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    45133125..45152577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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