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Asic2 acid-sensing ion channel 2 [ Mus musculus (house mouse) ]

Gene ID: 11418, updated on 18-Apr-2024

Summary

Official Symbol
Asic2provided by MGI
Official Full Name
acid-sensing ion channel 2provided by MGI
Primary source
MGI:MGI:1100867
See related
Ensembl:ENSMUSG00000020704 AllianceGenome:MGI:1100867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a
Summary
Enables ion gated channel activity and ligand-gated sodium channel activity. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.0), ovary adult (RPKM 9.0) and 10 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 48.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80770989..81859222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80880163..81968396, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930507D10 gene Neighboring gene sperm acrosome associated 3 Neighboring gene predicted gene, 51909 Neighboring gene STARR-seq mESC enhancer starr_30154 Neighboring gene predicted gene 11416 Neighboring gene STARR-seq mESC enhancer starr_30155 Neighboring gene STARR-seq mESC enhancer starr_30156 Neighboring gene STARR-seq mESC enhancer starr_30157 Neighboring gene STARR-seq mESC enhancer starr_30158 Neighboring gene predicted gene, 51910 Neighboring gene predicted gene, 42084 Neighboring gene STARR-seq mESC enhancer starr_30159 Neighboring gene STARR-seq mESC enhancer starr_30160 Neighboring gene STARR-seq mESC enhancer starr_30161 Neighboring gene RIKEN cDNA 1700071K01 gene Neighboring gene predicted gene 11418 Neighboring gene STARR-seq mESC enhancer starr_30167 Neighboring gene STARR-seq mESC enhancer starr_30168 Neighboring gene STARR-seq mESC enhancer starr_30169 Neighboring gene RIKEN cDNA 5530401A14 gene Neighboring gene predicted gene, 46254 Neighboring gene STARR-seq mESC enhancer starr_30170 Neighboring gene predicted gene 11419 Neighboring gene predicted gene, 31522 Neighboring gene C-C motif chemokine ligand 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ligand-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion-gated channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion-gated channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acid-sensing ion channel 2
Names
acid-sensing (proton-gated) ion channel 2
amiloride-sensitive brain sodium channel
amiloride-sensitive cation channel 1, neuronal (degenerin)
brain sodium channel 1
degenerin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034013.2NP_001029185.1  acid-sensing ion channel 2 isoform MDEG1

    See identical proteins and their annotated locations for NP_001029185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (MDEG1) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant MDEG2. The resulting isoform (MDEG1) is shorter and has a distinct N-terminus, compared to isoform MDEG2.
    Source sequence(s)
    AK134778, AL645842
    Consensus CDS
    CCDS36243.1
    UniProtKB/Swiss-Prot
    Q5SUU2, Q61203, Q925H0
    UniProtKB/TrEMBL
    Q3UYD3
    Related
    ENSMUSP00000067095.7, ENSMUST00000066197.7
    Conserved Domains (1) summary
    cl02990
    Location:18506
    ASC; Amiloride-sensitive sodium channel
  2. NM_007384.3NP_031410.1  acid-sensing ion channel 2 isoform MDEG2

    See identical proteins and their annotated locations for NP_031410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (MDEG2) is the longer transcript and encodes the longer isoform (MDEG2).
    Source sequence(s)
    AL645626, BB342826, BC138530, CJ282964
    Consensus CDS
    CCDS25137.1
    UniProtKB/TrEMBL
    B2RRQ1
    Related
    ENSMUSP00000021045.7, ENSMUST00000021045.13
    Conserved Domains (1) summary
    TIGR00859
    Location:64557
    ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80770989..81859222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531996.5XP_006532059.1  acid-sensing ion channel 2 isoform X1

    Conserved Domains (1) summary
    cl02990
    Location:64590
    ASC; Amiloride-sensitive sodium channel