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gm2a ganglioside GM2 activator [ Xiphophorus couchianus (Monterrey platyfish) ]

Gene ID: 114139626, updated on 15-Mar-2024

Summary

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Gene symbol
gm2a
Gene description
ganglioside GM2 activator
Gene type
protein coding
RefSeq status
MODEL
Organism
Xiphophorus couchianus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Xiphophorus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 23
Exon count:
4
Annotation release Status Assembly Chr Location
101 current X_couchianus-1.0 (GCF_001444195.1) 23 NC_040250.1 (12960486..12965947, complement)

Chromosome 23 - NC_040250.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114139263 Neighboring gene uncharacterized LOC114139267 Neighboring gene protocadherin 12 Neighboring gene shootin 3 Neighboring gene THO complex 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_040250.1 Chromosome 23 Reference X_couchianus-1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ganglioside GM2 activator
Names
GM2 ganglioside activator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xiphophorus couchianus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference X_couchianus-1.0 Primary Assembly

Genomic

  1. NC_040250.1 Reference X_couchianus-1.0 Primary Assembly

    Range
    12960486..12965947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028009663.1 → XP_027865464.1  ganglioside GM2 activator

    UniProtKB/TrEMBL
    A0A3B5L1J8
    Conserved Domains (1) summary
    cd00258
    Location:43 → 202
    GM2-AP; GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. ...
Nucleotide Protein
Heading Accession and Version

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