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SIGLEC11 sialic acid binding Ig like lectin 11 [ Homo sapiens (human) ]

Gene ID: 114132, updated on 5-Jan-2022

Summary

Official Symbol
SIGLEC11provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 11provided by HGNC
Primary source
HGNC:HGNC:15622
See related
Ensembl:ENSG00000161640 MIM:607157
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in ovary (RPKM 40.7), spleen (RPKM 13.8) and 1 other tissue See more
Orthologs
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Genomic context

See SIGLEC11 in Genome Data Viewer
Location:
19q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49948825..49961172, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50452242..50464429, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1 Neighboring gene nucleoporin 62 Neighboring gene microRNA 4751 Neighboring gene activating transcription factor 5 Neighboring gene sialic acid binding Ig like lectin 16 Neighboring gene VRK serine/threonine kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 11
Names
siglec-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030323.1 RefSeqGene

    Range
    5001..17188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135163.1NP_001128635.1  sialic acid-binding Ig-like lectin 11 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC011452, AF337818, AY358135
    Consensus CDS
    CCDS46150.1
    UniProtKB/Swiss-Prot
    Q96RL6
    Related
    ENSP00000398891.2, ENST00000426971.2
    Conserved Domains (4) summary
    cd00096
    Location:387450
    Ig; Immunoglobulin domain
    cd05712
    Location:34153
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:280341
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:275351
    IG_like; Immunoglobulin like
  2. NM_052884.3NP_443116.2  sialic acid-binding Ig-like lectin 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443116.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011452, AF337818
    Consensus CDS
    CCDS12790.2
    UniProtKB/Swiss-Prot
    Q96RL6
    Related
    ENSP00000412361.2, ENST00000447370.6
    Conserved Domains (4) summary
    cd00096
    Location:387450
    Ig; Immunoglobulin domain
    cd05712
    Location:34153
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:280341
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:275351
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49948825..49961172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258476.3XP_005258533.2  sialic acid-binding Ig-like lectin 11 isoform X1

    Conserved Domains (4) summary
    cd00096
    Location:371434
    Ig; Immunoglobulin domain
    cd05712
    Location:34153
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:264325
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259335
    IG_like; Immunoglobulin like
  2. XM_005258477.3XP_005258534.2  sialic acid-binding Ig-like lectin 11 isoform X2

    Conserved Domains (4) summary
    cd00096
    Location:387450
    Ig; Immunoglobulin domain
    cd05712
    Location:34153
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:280341
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:275351
    IG_like; Immunoglobulin like

RNA

  1. XR_243888.4 RNA Sequence

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