Format

Send to:

Choose Destination

UCN3 urocortin 3 [ Homo sapiens (human) ]

Gene ID: 114131, updated on 3-Jan-2019

Summary

Official Symbol
UCN3provided by HGNC
Official Full Name
urocortin 3provided by HGNC
Primary source
HGNC:HGNC:17781
See related
Ensembl:ENSG00000178473 MIM:605901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCP; SPC; UCNIII
Summary
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]
Expression
Biased expression in duodenum (RPKM 4.8), small intestine (RPKM 3.4) and 8 other tissues See more
Orthologs

Genomic context

See UCN3 in Genome Data Viewer
Location:
10p15.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (5365009..5374692)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5406976..5416169)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4527 Neighboring gene aldo-keto reductase family 1 member C7, pseudogene Neighboring gene ribosomal protein L26 pseudogene 28 Neighboring gene tubulin alpha like 3 Neighboring gene neuroepithelial cell transforming 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
NHGRI GWA Catalog

Pathways from BioSystems

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
corticotropin-releasing hormone receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 
corticotropin-releasing hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
corticotropin-releasing hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
digestion IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
urocortin-3
Names
prepro-urocortin 3
stresscopin
ucn III
urocortin III

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053049.4NP_444277.2  urocortin-3 preproprotein

    See identical proteins and their annotated locations for NP_444277.2

    Status: REVIEWED

    Source sequence(s)
    AL683826, AY026949, BQ776877, BQ777111, BQ778217, CK821206
    Consensus CDS
    CCDS7065.1
    UniProtKB/Swiss-Prot
    Q969E3
    Related
    ENSP00000369798.3, ENST00000380433.4
    Conserved Domains (1) summary
    pfam00473
    Location:120157
    CRF; Corticotropin-releasing factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    5365009..5374692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center