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Vegfc vascular endothelial growth factor C [ Rattus norvegicus (Norway rat) ]

Gene ID: 114111, updated on 15-Nov-2019

Summary

Official Symbol
Vegfcprovided by RGD
Official Full Name
vascular endothelial growth factor Cprovided by RGD
Primary source
RGD:619800
See related
Ensembl:ENSRNOG00000011416
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 77.7), Lung (RPKM 64.5) and 9 other tissues See more
Orthologs

Genomic context

See Vegfc in Genome Data Viewer
Location:
16p11
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (40440371..40555178, complement)
106 current Rn_Celera (GCF_000002265.2) 16 AC_000084.1 (35834400..35949683, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (40216307..40331753, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 5 Neighboring gene signal peptidase complex subunit 3 Neighboring gene uncharacterized LOC102549910 Neighboring gene glutathione S-transferase P pseudogene Neighboring gene RIKEN cDNA 2310037I24-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor 3 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor 3 binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor 3 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
vascular endothelial growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
PubMed 
induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of embryonic epithelium ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lymphangiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vascular endothelial growth factor C
Names
VEGF-C
VRP
flt4 ligand
flt4-L
vascular endothelial growth factor-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053653.1NP_446105.1  vascular endothelial growth factor C precursor

    See identical proteins and their annotated locations for NP_446105.1

    Status: PROVISIONAL

    Source sequence(s)
    AY032729
    UniProtKB/Swiss-Prot
    O35757
    Related
    ENSRNOP00000015529.2, ENSRNOT00000015529.4
    Conserved Domains (1) summary
    pfam00341
    Location:127207
    PDGF; PDGF/VEGF domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    40440371..40555178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    35834400..35949683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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