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Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 114096, updated on 8-Dec-2022

Summary

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Official Symbol
Idh3aprovided by RGD
Official Full Name
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alphaprovided by RGD
Primary source
RGD:70889
See related
Ensembl:ENSRNOG00000010277 AllianceGenome:RGD:70889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables isocitrate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Predicted to be part of mitochondrial isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1354.6), Heart (RPKM 836.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Idh3a in Genome Data Viewer
Location:
8q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54971694..54991085)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59164601..59183899)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, et al. Biochem Biophys Res Commun, 2001 Mar 2. PMID 11237704
  2. Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase. Huang YC, et al. Biochemistry, 1990 Sep 11. PMID 2252888
  3. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 18. PMID 28098230, Free PMC Article
  4. Preparation and properties of mitochondria derived from synaptosomes. Lai JC, et al. Biochem J, 1976 Feb 15. PMID 938457, Free PMC Article
  5. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables isocitrate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables isocitrate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in isocitrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial isocitrate dehydrogenase complex (NAD+) IC
Inferred by Curator
more info
 PubMed 
part_of mitochondrial isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Names
NAD(+)-specific ICDH subunit alpha
isocitrate dehydrogenase (NAD(+)) 3 alpha
isocitrate dehydrogenase 3 (NAD+) alpha
isocitric dehydrogenase subunit alpha
NP_446090.2
XP_038936589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053638.2 → NP_446090.2  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198
    Related
    ENSRNOP00000015102.4, ENSRNOT00000015102.5
    Conserved Domains (1) summary
    TIGR00175
    Location:29 → 362
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    54971694..54991085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080661.1 → XP_038936589.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR00175
    Location:38 → 370
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NA5.1 GenPept UniProtKB/Swiss-Prot:Q99NA5

Gene LinkOut

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