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Acads acyl-Coenzyme A dehydrogenase, short chain [ Mus musculus (house mouse) ]

Gene ID: 11409, updated on 27-Feb-2024

Summary

Official Symbol
Acadsprovided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase, short chainprovided by MGI
Primary source
MGI:MGI:87868
See related
Ensembl:ENSMUSG00000029545 AllianceGenome:MGI:87868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcd1; SCAD; Bcd-1; Hdlq8
Summary
This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
Expression
Broad expression in colon adult (RPKM 134.5), adrenal adult (RPKM 130.8) and 22 other tissues See more
Orthologs
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Genomic context

See Acads in Genome Data Viewer
Location:
5 55.99 cM; 5 F
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115248358..115257405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115110299..115119346, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_14099 Neighboring gene predicted gene, 54336 Neighboring gene ribosomal protein L37, retrotransposed Neighboring gene unc-119 lipid binding chaperone B Neighboring gene STARR-positive B cell enhancer ABC_E10342 Neighboring gene STARR-seq mESC enhancer starr_14100 Neighboring gene STARR-positive B cell enhancer ABC_E1058 Neighboring gene malectin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Phenotypes

Associated conditions

Description Tests
HDL QTL 8
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables butyryl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables butyryl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
enables short-chain fatty acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in butyrate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in butyrate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
short-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
butyryl-CoA dehydrogenase
NP_031409.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007383.3NP_031409.2  short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031409.2

    Status: REVIEWED

    Source sequence(s)
    AK169428, BE993251, BY077302
    Consensus CDS
    CCDS19579.1
    UniProtKB/Swiss-Prot
    Q07417, Q91W85
    Related
    ENSMUSP00000031524.8, ENSMUST00000031524.11
    Conserved Domains (1) summary
    cd01158
    Location:36408
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115248358..115257405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)