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TRIM9 tripartite motif containing 9 [ Homo sapiens (human) ]

Gene ID: 114088, updated on 3-Jun-2018
Official Symbol
TRIM9provided by HGNC
Official Full Name
tripartite motif containing 9provided by HGNC
Primary source
HGNC:HGNC:16288
See related
Ensembl:ENSG00000100505 MIM:606555; Vega:OTTHUMG00000140291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF91; SPRING
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 15.3), gall bladder (RPKM 1.4) and 1 other tissue See more
Orthologs
See TRIM9 in Genome Data Viewer
Location:
14q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (50975261..51105173, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (51441979..51562422, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene PYGL intron CAGE-defined low expression enhancer Neighboring gene uncharacterized LOC105370492 Neighboring gene glycogen phosphorylase L Neighboring gene uncharacterized LOC400212 Neighboring gene thioredoxin related transmembrane protein 1 Neighboring gene long intergenic non-protein coding RNA 519

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase TRIM9
Names
RING finger protein 91
RING-type E3 ubiquitin transferase TRIM9
homolog of rat RING finger Spring
tripartite motif-containing protein 9
NP_055978.4
NP_443210.1
XP_005267358.1
XP_005267359.1
XP_006720081.1
XP_011534691.1
XP_016876432.1
XP_016876433.1
XP_016876434.1
XP_016876435.1
XP_016876436.1
XP_016876437.1
XP_016876438.1
XP_016876439.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015163.5NP_055978.4  E3 ubiquitin-protein ligase TRIM9 isoform 1

    See identical proteins and their annotated locations for NP_055978.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC063872, D87458, DA101991, DA173440
    Consensus CDS
    CCDS9703.1
    UniProtKB/Swiss-Prot
    Q9C026
    Related
    ENSP00000298355.3, OTTHUMP00000178971, ENST00000298355.7, OTTHUMT00000276874
    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:529700
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  2. NM_052978.4NP_443210.1  E3 ubiquitin-protein ligase TRIM9 isoform 2

    See identical proteins and their annotated locations for NP_443210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, resulting in a frameshift and an earlier stop codon as compared to variant 1. Isoform 2 is shorter than isoform 1 and has a distinct C-terminus.
    Source sequence(s)
    BC013414, BC063872, DA101991, T77638
    Consensus CDS
    CCDS45105.1
    UniProtKB/Swiss-Prot
    Q9C026
    Related
    ENSP00000353561.4, OTTHUMP00000244861, ENST00000360392.4, OTTHUMT00000411204
    Conserved Domains (4) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl17238
    Location:552
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    50975261..51105173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020950.1XP_016876439.1  E3 ubiquitin-protein ligase TRIM9 isoform X12

  2. XM_017020949.1XP_016876438.1  E3 ubiquitin-protein ligase TRIM9 isoform X11

    Conserved Domains (4) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:434601
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  3. XM_017020948.1XP_016876437.1  E3 ubiquitin-protein ligase TRIM9 isoform X10

  4. XM_017020946.1XP_016876435.1  E3 ubiquitin-protein ligase TRIM9 isoform X8

  5. XM_017020943.1XP_016876432.1  E3 ubiquitin-protein ligase TRIM9 isoform X3

  6. XM_017020947.1XP_016876436.1  E3 ubiquitin-protein ligase TRIM9 isoform X9

  7. XM_017020945.1XP_016876434.1  E3 ubiquitin-protein ligase TRIM9 isoform X7

    UniProtKB/Swiss-Prot
    Q9C026
    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:529700
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  8. XM_005267302.3XP_005267359.1  E3 ubiquitin-protein ligase TRIM9 isoform X6

    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:557704
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  9. XM_017020944.1XP_016876433.1  E3 ubiquitin-protein ligase TRIM9 isoform X5

  10. XM_005267301.3XP_005267358.1  E3 ubiquitin-protein ligase TRIM9 isoform X4

    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:620767
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  11. XM_006720018.3XP_006720081.1  E3 ubiquitin-protein ligase TRIM9 isoform X2

    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:620785
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
  12. XM_011536389.2XP_011534691.1  E3 ubiquitin-protein ligase TRIM9 isoform X1

    UniProtKB/Swiss-Prot
    Q9C026
    Related
    ENSP00000342970.5, OTTHUMP00000178972, ENST00000338969.9, OTTHUMT00000276875
    Conserved Domains (5) summary
    smart00502
    Location:273399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:449528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:938
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:616773
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

RNA

  1. XR_001750136.1 RNA Sequence

  2. XR_002957528.1 RNA Sequence

  3. XR_001750135.1 RNA Sequence

  4. XR_002957527.1 RNA Sequence

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