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LINC00313 long intergenic non-protein coding RNA 313 [ Homo sapiens (human) ]

Gene ID: 114038, updated on 21-Mar-2023

Summary

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Official Symbol
LINC00313provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 313provided by HGNC
Primary source
HGNC:HGNC:16416
See related
Ensembl:ENSG00000185186 AllianceGenome:HGNC:16416
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C21orf84; NCRNA00313; CH507-42P11.5
Expression
Broad expression in adrenal (RPKM 1.4), liver (RPKM 1.3) and 18 other tissues See more
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Genomic context

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See LINC00313 in Genome Data Viewer
Location:
21q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43462094..43478223, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41817358..41833775, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44881974..44898103, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene SIK1-LINC00319 intergenic CAGE-defined high expression enhancer Neighboring gene uncharacterized LOC124900467 Neighboring gene long intergenic non-protein coding RNA 319 Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene uncharacterized LOC102723380 Neighboring gene Sharpr-MPRA regulatory region 2841 Neighboring gene Sharpr-MPRA regulatory region 13752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00313 regulates the metastasis of testicular germ cell tumors through epithelial-mesenchyme transition and immune pathways. Liu Z, et al. Bioengineered, 2022 May. PMID 35575252, Free PMC Article
  2. Differentially expressed protein-coding genes and long noncoding RNA in early-stage lung cancer. Li M, et al. Tumour Biol, 2015 Dec. PMID 26178480
  3. LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis and prognosis of non-small cell lung cancer. Wang J, et al. Acta Biochim Pol, 2022 Apr 28. PMID 35485050
  4. Downregulated long noncoding RNA LINC00313 inhibits the epithelial-mesenchymal transition, invasion, and migration of thyroid cancer cells through inhibiting the methylation of ALX4. Zhao X, et al. J Cell Physiol, 2019 Nov. PMID 31093972
  5. SP1-induced upregulation of long noncoding RNA LINC00313 contributes to papillary thyroid cancer progression via the miR-422a. Yan DG, et al. Eur Rev Med Pharmacol Sci, 2019 Feb. PMID 30779082

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis.
    Title: LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis.
  2. LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis and prognosis of non-small cell lung cancer.
    Title: LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis and prognosis of non-small cell lung cancer.
  3. LINC00313 regulates the metastasis of testicular germ cell tumors through epithelial-mesenchyme transition and immune pathways.
    Title: LINC00313 regulates the metastasis of testicular germ cell tumors through epithelial-mesenchyme transition and immune pathways.
  4. LINC00313 functioned as an oncogene in papillary thyroid cancer in part through serving as a competing endogenous RNA to modulate mi-422a expression.
    Title: SP1-induced upregulation of long noncoding RNA LINC00313 contributes to papillary thyroid cancer progression via the miR-422a.
  5. LINC00313 acts as an oncogene in papillary thyroid cancer via sponging miR-4429
    Title: Long noncoding RNA LINC00313 modulates papillary thyroid cancer tumorigenesis via sponging miR-4429.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Clone Names

  • MGC129789

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF426261
    Related
    ENST00000332440.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    43462094..43478223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    41817358..41833775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153752.1: Suppressed sequence

    Description
    NM_153752.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59037.1 GenPept UniProtKB/Swiss-Prot:P59037

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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