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TOE1 target of EGR1, exonuclease [ Homo sapiens (human) ]

Gene ID: 114034, updated on 6-Nov-2022

Summary

Official Symbol
TOE1provided by HGNC
Official Full Name
target of EGR1, exonucleaseprovided by HGNC
Primary source
HGNC:HGNC:15954
See related
Ensembl:ENSG00000132773 MIM:613931; AllianceGenome:HGNC:15954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCH7; TOE-1; hCaf1z
Summary
Enables poly(A)-specific ribonuclease activity and snRNA binding activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Located in Cajal body and cytoplasm. Implicated in pontocerebellar hypoplasia type 7. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.9), bone marrow (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See TOE1 in Genome Data Viewer
Location:
1p34.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45340170..45343973)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45211727..45215530)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45805842..45809645)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12838 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase like Neighboring gene mutY DNA glycosylase Neighboring gene small nucleolar RNA U13 Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene peptidylprolyl isomerase A pseudogene 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, target of EGR1 member 1 (TOE1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with TOE1 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, exonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
target of EGR1 protein 1
Names
target of EGR1, member 1 (nuclear)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025077.4NP_079353.3  target of EGR1 protein 1

    See identical proteins and their annotated locations for NP_079353.3

    Status: VALIDATED

    Source sequence(s)
    AY169960, BC009364, DA887065
    Consensus CDS
    CCDS521.1
    UniProtKB/Swiss-Prot
    Q96GM8, Q9H846
    Related
    ENSP00000361162.5, ENST00000372090.6
    Conserved Domains (2) summary
    pfam00642
    Location:297320
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04857
    Location:41257
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45340170..45343973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270413.6XP_005270470.1  target of EGR1 protein 1 isoform X2

    Related
    ENST00000495703.5
    Conserved Domains (2) summary
    pfam00642
    Location:251274
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04857
    Location:2211
    CAF1; CAF1 family ribonuclease
  2. XM_005270412.5XP_005270469.1  target of EGR1 protein 1 isoform X1

    Conserved Domains (2) summary
    pfam00642
    Location:303326
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04857
    Location:47263
    CAF1; CAF1 family ribonuclease
  3. XM_047443512.1XP_047299468.1  target of EGR1 protein 1 isoform X5

    Related
    ENST00000471337.5
  4. XM_047443500.1XP_047299456.1  target of EGR1 protein 1 isoform X3

  5. XM_047443504.1XP_047299460.1  target of EGR1 protein 1 isoform X4

    UniProtKB/TrEMBL
    B4DP23

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45211727..45215530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)