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Ctnnd2 catenin delta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114028, updated on 22-Aug-2021

Summary

Official Symbol
Ctnnd2provided by RGD
Official Full Name
catenin delta 2provided by RGD
Primary source
RGD:620734
See related
Ensembl:ENSRNOG00000010649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog binds specifically to presenilin 1 (Psen1) [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 119.0) and Thymus (RPKM 8.0) See more
Orthologs
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Genomic context

See Ctnnd2 in Genome Data Viewer
Location:
2q22
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (81168976..82016495)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (83227247..84094315)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102553378 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC102553574 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
catenin delta-2
Names
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271502.1NP_001258431.1  catenin delta-2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000066
    UniProtKB/TrEMBL
    F1M787
    Related
    ENSRNOP00000045121.4, ENSRNOT00000044871.4
    Conserved Domains (4) summary
    cd00020
    Location:527649
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam00514
    Location:817858
    Arm; Armadillo/beta-catenin-like repeat
    pfam17052
    Location:10371096
    CAF20; Cap associated factor
    sd00043
    Location:535560
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    81168976..82016495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590573.2XP_017446062.1  catenin delta-2 isoform X1

  2. XM_006232094.4XP_006232156.2  catenin delta-2 isoform X2

  3. XM_039101550.1XP_038957478.1  catenin delta-2 isoform X4

    Conserved Domains (5) summary
    smart00185
    Location:502542
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:471644
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:61468
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:473498
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:755796
    Arm; Armadillo/beta-catenin-like repeat
  4. XM_039101551.1XP_038957479.1  catenin delta-2 isoform X5

    Conserved Domains (5) summary
    smart00185
    Location:487527
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:456629
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:46453
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:458483
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:740781
    Arm; Armadillo/beta-catenin-like repeat
  5. XM_039101549.1XP_038957477.1  catenin delta-2 isoform X3

    Conserved Domains (5) summary
    smart00185
    Location:521561
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:490663
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:80487
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:492517
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:774815
    Arm; Armadillo/beta-catenin-like repeat
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