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Acsl4 acyl-CoA synthetase long-chain family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113976, updated on 27-Nov-2024

Summary

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Official Symbol
Acsl4provided by RGD
Official Full Name
acyl-CoA synthetase long-chain family member 4provided by RGD
Primary source
RGD:69401
See related
EnsemblRapid:ENSRNOG00000019180 AllianceGenome:RGD:69401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acs4; Facl4
Summary
Enables arachidonate-CoA ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 1568.8), Liver (RPKM 1018.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acsl4 in Genome Data Viewer
Location:
Xq33
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (110739633..110803416, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (105942794..106006573, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (113596247..113660024, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099292 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5 Neighboring gene ribosomal protein L39 like 2 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis. Qu XF, et al. CNS Neurosci Ther, 2021 Apr. PMID 33314758, Free PMC Article
  2. Regulation and role of Acyl-CoA synthetase 4 in glial cells. Dattilo MA, et al. J Steroid Biochem Mol Biol, 2021 Apr. PMID 33246155
  3. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Kang MJ, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096315, Free PMC Article
  4. Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. Shimshoni JA, et al. Biochim Biophys Acta, 2011 Mar. PMID 21184843, Free PMC Article
  5. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. Klett EL, et al. J Biol Chem, 2013 Jul 26. PMID 23766516, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
    Title: ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
  2. METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m[6]A modification.
    Title: METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m(6)A modification.
  3. YAP Facilitates NEDD4L-Mediated Ubiquitination and Degradation of ACSL4 to Alleviate Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
    Title: YAP Facilitates NEDD4L-Mediated Ubiquitination and Degradation of ACSL4 to Alleviate Ferroptosis in Myocardial Ischemia-Reperfusion Injury.
  4. Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis.
    Title: Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis.
  5. Regulation and role of Acyl-CoA synthetase 4 in glial cells.
    Title: Regulation and role of Acyl-CoA synthetase 4 in glial cells.
  6. Upregulation of ACSL4 is responsible for the increase in triacylglycerol species containing long polyunsaturated fatty acids during activation of hepatic stellate cells.
    Title: Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.
  7. Acsl isozymes play distinct roles in the control of AA remodeling in rat fibroblasts: Acsl4 acts as the first step of enzyme for AA remodeling following IL-1beta stimulation, and Acsl1 is involved in the maintenance of some AA-containing PC species.
    Title: Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts.
  8. Results suggest that long chain acyl-CoA synthetase Acsl4 activates epoxyeicosatrienoic acids (EETs) to form EET-CoAs that are incorporated into glycerophospholipids, thereby sequestering EETs
    Title: Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.
  9. These results indicate that the ACS4 protein specifically expressed in brain plays an important role in arachidonate metabolism and neuronal differentiation in the brain.
    Title: A novel role of brain-type ACS4 isotype in neuronal differentiation.
  10. the involvement of SHP2 activity in the regulation of the expression of the fatty acid-metabolizing enzyme ACSL4
    Title: Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to interleukin-15 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 4
Names
LACS 4
arachidonate--CoA ligase
fatty acid-Coenzyme A ligase, long chain 4
long-chain acyl-CoA synthetase 4
NP_446075.1
XP_006257376.1
XP_006257377.1
XP_006257378.1
XP_038955322.1
XP_038955323.1
XP_063135802.1
XP_063135803.1
XP_063135804.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431649.1 → NP_001418578.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    O35547

  2. NM_001431650.1 → NP_001418579.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    O35547

  3. NM_001431651.1 → NP_001418580.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6KG71

  4. NM_001431652.1 → NP_001418581.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6KG71

  5. NM_001431653.1 → NP_001418582.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6KG71

  6. NM_001431654.1 → NP_001418583.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6KG71

  7. NM_001431655.1 → NP_001418584.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    O35547

  8. NM_053623.2 → NP_446075.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

    See identical proteins and their annotated locations for NP_446075.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6AVE1, A6KG71
    Related
    ENSRNOP00000026057.5, ENSRNOT00000026057.8
    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    110739633..110803416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099394.2 → XP_038955322.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

    Conserved Domains (1) summary
    cd17639
    Location:121 → 696
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  2. XM_006257314.5 → XP_006257376.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

    Related
    ENSRNOP00000103546.1, ENSRNOT00000130558.1
    Conserved Domains (1) summary
    cd17639
    Location:121 → 696
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  3. XM_006257316.4 → XP_006257378.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  4. XM_063279734.1 → XP_063135804.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

  5. XM_006257315.5 → XP_006257377.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

    Conserved Domains (1) summary
    cd17639
    Location:80 → 655
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

  6. XM_063279733.1 → XP_063135803.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

  7. XM_063279732.1 → XP_063135802.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

  8. XM_039099395.2 → XP_038955323.1  long-chain-fatty-acid--CoA ligase 4 isoform X3

    Conserved Domains (2) summary
    PRK04813
    Location:233 → 296
    PRK04813; D-alanine--poly(phosphoribitol) ligase subunit DltA
    cl17068
    Location:121 → 479
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35547.2 GenPept UniProtKB/Swiss-Prot:O35547

Gene LinkOut

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