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Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113970, updated on 3-Oct-2018

Summary

Official Symbol
Magi2provided by RGD
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 2provided by RGD
Primary source
RGD:621855
See related
Ensembl:ENSRNOG00000013962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
S-SCAM; Acvrip1; Acvrinp1
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 125.0), Testes (RPKM 44.7) and 4 other tissues See more
Orthologs

Genomic context

See Magi2 in Genome Data Viewer
Location:
4q11
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10995241..12472423, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (10987831..12456502, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556088 Neighboring gene putative homeodomain transcription factor 2 Neighboring gene uncharacterized LOC108350832 Neighboring gene ribosome biogenesis protein NSA2 homolog Neighboring gene uncharacterized LOC108350831 Neighboring gene thymosin beta-10 pseudogene Neighboring gene lamin-B2-like Neighboring gene uncharacterized LOC103692030 Neighboring gene uncharacterized LOC102547160 Neighboring gene hypothetical LOC100365492 Neighboring gene DNA-(apurinic or apyrimidinic site) lyase-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-1 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-1 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
beta-1 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-1 adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling complex scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor signaling complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling complex scaffold activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling complex scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
structural constituent of postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
structural constituent of postsynaptic specialization IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of postsynaptic specialization IMP
Inferred from Mutant Phenotype
more info
PubMed 
type II activin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II activin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type II activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
type II activin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nerve growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glomerular filtration IC
Inferred by Curator
more info
PubMed 
glomerular visceral epithelial cell development IEP
Inferred from Expression Pattern
more info
PubMed 
maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of activin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
nerve growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neuroligin clustering involved in postsynaptic membrane assembly IEA
Inferred from Electronic Annotation
more info
 
neuroligin clustering involved in postsynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
slit diaphragm IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Names
AIP-1
MAGI-2
activin receptor interacting protein 1
atrophin-1-interacting protein 1
membrane-associated guanylate kinase inverted 2
synaptic-scaffolding molecule

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053621.1NP_446073.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

    See identical proteins and their annotated locations for NP_446073.1

    Status: PROVISIONAL

    Source sequence(s)
    AF034863
    UniProtKB/Swiss-Prot
    O88382
    Related
    ENSRNOP00000059912.3, ENSRNOT00000066643.3
    Conserved Domains (6) summary
    smart00072
    Location:118291
    GuKc; Guanylate kinase homologues
    smart00228
    Location:775861
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:305335
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:11401220
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:350379
    WW; WW domain
    pfam16666
    Location:682756
    MAGI_u5; Unstructured region on MAGI

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    10995241..12472423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    9948183..11419535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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