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Acaa1a acetyl-Coenzyme A acyltransferase 1A [ Mus musculus (house mouse) ]

Gene ID: 113868, updated on 2-Oct-2018

Summary

Official Symbol
Acaa1aprovided by MGI
Official Full Name
acetyl-Coenzyme A acyltransferase 1Aprovided by MGI
Primary source
MGI:MGI:2148491
See related
Ensembl:ENSMUSG00000036138 Vega:OTTMUSG00000042191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTL; Acaa; Acaa1; D9Ertd25e
Expression
Ubiquitous expression in duodenum adult (RPKM 294.0), liver adult (RPKM 221.7) and 26 other tissues See more

Genomic context

See Acaa1a in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (119341052..119350296)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (119250412..119259413)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene oxidative-stress responsive 1 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene xylulokinase homolog (H. influenzae) Neighboring gene activin receptor IIB

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7090

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA C-acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
peroxisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
3-ketoacyl-CoA thiolase A, peroxisomal
Names
acetyl-CoA acyltransferase A
beta-ketothiolase A
peroxisomal 3-ketoacyl-CoA thiolase
peroxisomal 3-oxoacyl-CoA thiolase A
peroxisomal 3-oxoacyl-Coenzyme A thiolase
thiolase A
NP_570934.1
XP_006511986.1
XP_006511987.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357516.1NP_001344445.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC128702
    Conserved Domains (1) summary
    cl27751
    Location:1268
    Thiolase_N; Thiolase, N-terminal domain
  2. NM_130864.3NP_570934.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 precursor

    See identical proteins and their annotated locations for NP_570934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC128702
    Consensus CDS
    CCDS23613.1
    UniProtKB/Swiss-Prot
    Q921H8
    Related
    ENSMUSP00000042351.5, OTTMUSP00000061838, ENSMUST00000039784.11, OTTMUST00000110753
    Conserved Domains (2) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase
    cd00751
    Location:39421
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    119341052..119350296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511923.1XP_006511986.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X1

    See identical proteins and their annotated locations for XP_006511986.1

    UniProtKB/Swiss-Prot
    Q921H8
    Conserved Domains (2) summary
    PLN02287
    Location:1420
    PLN02287; 3-ketoacyl-CoA thiolase
    cd00751
    Location:39421
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
  2. XM_006511924.3XP_006511987.1  3-ketoacyl-CoA thiolase A, peroxisomal isoform X2

    Conserved Domains (1) summary
    cl27751
    Location:1268
    Thiolase_N; Thiolase, N-terminal domain
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