Format

Send to:

Choose Destination

PIK3IP1 phosphoinositide-3-kinase interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 113791, updated on 10-Oct-2019

Summary

Official Symbol
PIK3IP1provided by HGNC
Official Full Name
phosphoinositide-3-kinase interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:24942
See related
Ensembl:ENSG00000100100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGFL; TrIP; hHGFL(S)
Expression
Ubiquitous expression in lymph node (RPKM 60.4), appendix (RPKM 38.3) and 23 other tissues See more
Orthologs

Genomic context

See PIK3IP1 in Genome Data Viewer
Location:
22q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31281593..31292534, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31677579..31688833, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 2 Neighboring gene RNA, U6 small nuclear 1128, pseudogene Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 1 Neighboring gene uncharacterized LOC105372997 Neighboring gene RNA, 5S ribosomal pseudogene 496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol 3-kinase catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide-3-kinase-interacting protein 1
Names
kringle domain-containing protein HGFL
transmembrane inhibitor of PI3K

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135911.1NP_001129383.1  phosphoinositide-3-kinase-interacting protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001129383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, early translation termination and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC002073, AK299397, AW005175, DC412134
    Consensus CDS
    CCDS46690.1
    UniProtKB/Swiss-Prot
    Q96FE7
    Related
    ENSP00000415608.1, ENST00000441972.5
    Conserved Domains (1) summary
    cd00108
    Location:22102
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
  2. NM_052880.5NP_443112.2  phosphoinositide-3-kinase-interacting protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443112.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC002073, AW005175, DC412134
    Consensus CDS
    CCDS13893.1
    UniProtKB/Swiss-Prot
    Q96FE7
    UniProtKB/TrEMBL
    A0A024R1M3
    Related
    ENSP00000215912.4, ENST00000215912.10
    Conserved Domains (1) summary
    cd00108
    Location:22102
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    31281593..31292534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center