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PIK3IP1 phosphoinositide-3-kinase interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 113791, updated on 1-Mar-2024

Summary

Official Symbol
PIK3IP1provided by HGNC
Official Full Name
phosphoinositide-3-kinase interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:24942
See related
Ensembl:ENSG00000100100 MIM:619158; AllianceGenome:HGNC:24942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGFL; TrIP; hHGFL(S)
Summary
Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in negative regulation of phosphatidylinositol 3-kinase activity and negative regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 60.4), appendix (RPKM 38.3) and 23 other tissues See more
Orthologs
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Genomic context

See PIK3IP1 in Genome Data Viewer
Location:
22q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31281593..31292534, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31745576..31756513, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31677579..31688520, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 2 Neighboring gene RNA, U6 small nuclear 1128, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31643479-31644369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31644370-31645259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31672194-31672774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31674451-31674951 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18854 Neighboring gene uncharacterized LOC105372997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18855 Neighboring gene RNA, 5S ribosomal pseudogene 496

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC17330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol 3-kinase inhibitor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol 3-kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide-3-kinase-interacting protein 1
Names
PI3K-interacting protein 1
kringle domain-containing protein HGFL
transmembrane inhibitor of PI3K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135911.1NP_001129383.1  phosphoinositide-3-kinase-interacting protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001129383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, early translation termination and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC002073, AK299397, AW005175, DC412134
    Consensus CDS
    CCDS46690.1
    UniProtKB/Swiss-Prot
    Q96FE7
    Related
    ENSP00000415608.1, ENST00000441972.5
    Conserved Domains (1) summary
    cd00108
    Location:22102
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
  2. NM_052880.5NP_443112.2  phosphoinositide-3-kinase-interacting protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443112.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC002073, AW005175, DC412134
    Consensus CDS
    CCDS13893.1
    UniProtKB/Swiss-Prot
    B4DRR9, D1MEI0, O00318, Q49A94, Q86YW2, Q8NCJ9, Q96FE7
    UniProtKB/TrEMBL
    B4DV97
    Related
    ENSP00000215912.4, ENST00000215912.10
    Conserved Domains (1) summary
    cd00108
    Location:22102
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31281593..31292534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31745576..31756513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)