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ODF3 outer dense fiber of sperm tails 3 [ Homo sapiens (human) ]

Gene ID: 113746, updated on 17-Jun-2019

Summary

Official Symbol
ODF3provided by HGNC
Official Full Name
outer dense fiber of sperm tails 3provided by HGNC
Primary source
HGNC:HGNC:19905
See related
Ensembl:ENSG00000177947 MIM:608356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT135; TISP50; SHIPPO1
Summary
ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]
Expression
Restricted expression toward testis (RPKM 3.9) See more
Orthologs

Genomic context

See ODF3 in Genome Data Viewer
Location:
11p15.5
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (196761..200258)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (196761..200273)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC388572 Neighboring gene uncharacterized LOC101930129 Neighboring gene secretoglobin family 1C member 1 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene microRNA 6743

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
NHGRI GWA Catalog
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of outer dense fiber of sperm tails 3 (ODF3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
outer dense fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
outer dense fiber protein 3
Names
cancer/testis antigen 135
sperm tail protein SHIPPO1
transcript induced in spermiogenesis protein 50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286136.1NP_001273065.1  outer dense fiber protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001273065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB067774, BC144022
    Consensus CDS
    CCDS65981.1
    UniProtKB/Swiss-Prot
    Q96PU9
    Related
    ENSP00000436588.1, ENST00000525282.1
  2. NM_053280.4NP_444510.2  outer dense fiber protein 3 isoform 1

    See identical proteins and their annotated locations for NP_444510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB067774, AL133658
    Consensus CDS
    CCDS7688.1
    UniProtKB/Swiss-Prot
    Q96PU9
    Related
    ENSP00000325868.4, ENST00000325113.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    196761..200258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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