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CIMAP1A ciliary microtubule associated protein 1A [ Homo sapiens (human) ]

Gene ID: 113746, updated on 17-Sep-2024

Summary

Official Symbol
CIMAP1Aprovided by HGNC
Official Full Name
ciliary microtubule associated protein 1Aprovided by HGNC
Primary source
HGNC:HGNC:19905
See related
Ensembl:ENSG00000177947 MIM:608356; AllianceGenome:HGNC:19905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODF3; CT135; TISP50; SHIPPO1
Summary
ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]
Expression
Restricted expression toward testis (RPKM 3.9) See more
Orthologs
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Genomic context

See CIMAP1A in Genome Data Viewer
Location:
11p15.5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (196761..200258)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (237936..241436)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (196761..200258)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101930129 Neighboring gene secretoglobin family 1C member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:205815-206314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:206625-207126 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:207673-208294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:208295-208914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:208989-209576 Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene microRNA 6743

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
EBI GWAS Catalog
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of outer dense fiber of sperm tails 3 (ODF3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in outer dense fiber IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ciliary microtubule associated protein 1A
Names
cancer/testis antigen 135
outer dense fiber of sperm tails 3
outer dense fiber protein 3
sperm tail protein SHIPPO1
transcript induced in spermiogenesis protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286136.2NP_001273065.1  ciliary microtubule associated protein 1A isoform 2

    See identical proteins and their annotated locations for NP_001273065.1

    Status: VALIDATED

    Source sequence(s)
    AC069287
    Consensus CDS
    CCDS65981.1
    UniProtKB/Swiss-Prot
    Q96PU9
    Related
    ENSP00000436588.1, ENST00000525282.1
  2. NM_053280.5NP_444510.2  ciliary microtubule associated protein 1A isoform 1

    See identical proteins and their annotated locations for NP_444510.2

    Status: VALIDATED

    Source sequence(s)
    AC069287
    Consensus CDS
    CCDS7688.1
    UniProtKB/Swiss-Prot
    B7ZLT0, Q69YX0, Q96PU9
    Related
    ENSP00000325868.5, ENST00000325113.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    196761..200258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    237936..241436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)