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Acadvl acyl-Coenzyme A dehydrogenase, very long chain [ Mus musculus (house mouse) ]

Gene ID: 11370, updated on 1-Mar-2024

Summary

Official Symbol
Acadvlprovided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase, very long chainprovided by MGI
Primary source
MGI:MGI:895149
See related
Ensembl:ENSMUSG00000018574 AllianceGenome:MGI:895149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vlcad
Summary
This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]
Expression
Broad expression in heart adult (RPKM 185.6), liver E18 (RPKM 80.6) and 25 other tissues See more
Orthologs
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Genomic context

See Acadvl in Genome Data Viewer
Location:
11 B3; 11 42.96 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69901009..69906254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70010183..70015428, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69808904-69809245 Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene microRNA 324 Neighboring gene STARR-positive B cell enhancer ABC_E11483 Neighboring gene STARR-positive B cell enhancer ABC_E1421 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E2358 Neighboring gene asialoglycoprotein receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
MVLCAD
NP_059062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017366.3NP_059062.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_059062.1

    Status: REVIEWED

    Source sequence(s)
    AI843782, AK076037, AU067294
    Consensus CDS
    CCDS24931.1
    UniProtKB/Swiss-Prot
    O35289, O55133, P50544
    UniProtKB/TrEMBL
    B1AR28
    Related
    ENSMUSP00000099634.4, ENSMUST00000102574.10
    Conserved Domains (2) summary
    cd01161
    Location:73482
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:95474
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69901009..69906254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)