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SDSL serine dehydratase like [ Homo sapiens (human) ]

Gene ID: 113675, updated on 7-Jun-2020

Summary

Official Symbol
SDSLprovided by HGNC
Official Full Name
serine dehydratase likeprovided by HGNC
Primary source
HGNC:HGNC:30404
See related
Ensembl:ENSG00000139410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDH; cSDH; SDH 2; SDS-RS1
Expression
Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 24 other tissues See more
Orthologs

Genomic context

See SDSL in Genome Data Viewer
Location:
12q24.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113422265..113438277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113860042..113876081)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369989 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase Neighboring gene LIM homeobox 5 Neighboring gene LHX5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-threonine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-threonine catabolic process to glycine TAS
Traceable Author Statement
more info
 
biological_process ND
No biological Data available
more info
 
isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
serine dehydratase 2
serine dehydratase related sequence 1
NP_001291922.1
NP_612441.1
XP_005253888.1
XP_011536148.1
XP_016874252.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304993.2NP_001291922.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_001291922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC091479
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Related
    ENSP00000385790.4, ENST00000403593.9
    Conserved Domains (2) summary
    pfam00291
    Location:18310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. NM_138432.3NP_612441.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_612441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC009849
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Related
    ENSP00000341117.4, ENST00000345635.8
    Conserved Domains (2) summary
    pfam00291
    Location:18310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    113422265..113438277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537846.2XP_011536148.1  serine dehydratase-like isoform X2

    See identical proteins and their annotated locations for XP_011536148.1

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Conserved Domains (2) summary
    pfam00291
    Location:18310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. XM_005253831.5XP_005253888.1  serine dehydratase-like isoform X2

    See identical proteins and their annotated locations for XP_005253888.1

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Conserved Domains (2) summary
    pfam00291
    Location:18310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. XM_017018763.1XP_016874252.1  serine dehydratase-like isoform X1

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