U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SDSL serine dehydratase like [ Homo sapiens (human) ]

Gene ID: 113675, updated on 6-Jul-2026
Official Symbol
SDSLprovided by HGNC
Official Full Name
serine dehydratase likeprovided by HGNC
Primary source
HGNC:HGNC:30404
See related
Ensembl:ENSG00000139410 MIM:620735; AllianceGenome:HGNC:30404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDHL; cSDH; SDH 2; SDS-RS1
Summary
Enables L-serine ammonia-lyase activity; identical protein binding activity; and threonine deaminase activity. Predicted to be involved in L-serine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 24 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SDSL in Genome Data Viewer
Location:
12q24.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (113422380..113438276)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (113399004..113414868)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113860185..113876081)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113797151-113797650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113801516-113802016 Neighboring gene phospholipase B domain containing 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113818149-113818674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839129-113839630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839631-113840130 Neighboring gene serine dehydratase Neighboring gene ReSE screen-validated silencer GRCh37_chr12:113851189-113851372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113855942-113856442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113905667-113906660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113908758-113909558 Neighboring gene LIM homeobox 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113916060-113917027 Neighboring gene LHX5 antisense RNA 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Enzymatic and biochemical properties of a novel human serine dehydratase isoform. Ogawa H, et al. Biochim Biophys Acta, 2006 May. PMID 16580895
  2. A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. Yamada T, et al. Biochim Biophys Acta, 2008 May. PMID 18342636
  3. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article
  4. A protein interaction landscape of breast cancer. Kim M, et al. Science, 2021 Oct. PMID 34591612, Free PMC Article
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  2. The crystal structure of SDSL has been determined. Site-directed mutagenesis studies suggest that having a glycine at residue 72 of SDSL is the major reason for the reduction of its catalytic activity, in comparison with the liver enzyme (SDS).
    Title: A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity EXP
Inferred from Experiment
more info
 PubMed 
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate racemase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate racemase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine deaminase activity EXP
Inferred from Experiment
more info
 PubMed 
enables threonine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
cancerous serine dehydratase
glutamate racemase
serine dehydratase 2
serine dehydratase related sequence 1
NP_001291922.1
NP_612441.1
XP_005253888.1
XP_016874252.1
XP_054226953.1
XP_054226954.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304993.2 → NP_001291922.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_001291922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC091479
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0ACI8R2W3
    Related
    ENSP00000385790.4, ENST00000403593.9
    Conserved Domains (2) summary
    pfam00291
    Location:18 → 310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17 → 326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

  2. NM_138432.4 → NP_612441.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_612441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC009849
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0ACI8R2W3
    Related
    ENSP00000341117.4, ENST00000345635.8
    Conserved Domains (2) summary
    pfam00291
    Location:18 → 310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17 → 326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    113422380..113438276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018763.2 → XP_016874252.1  serine dehydratase-like isoform X1

    UniProtKB/TrEMBL
    A0ACI8R2W3

  2. XM_005253831.6 → XP_005253888.1  serine dehydratase-like isoform X2

    See identical proteins and their annotated locations for XP_005253888.1

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0ACI8R2W3
    Related
    ENSP00000544106.1, ENST00000874047.1
    Conserved Domains (2) summary
    pfam00291
    Location:18 → 310
    PALP; Pyridoxal-phosphate dependent enzyme
    cl00342
    Location:17 → 326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    113399004..113414868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370978.1 → XP_054226953.1  serine dehydratase-like isoform X1

    UniProtKB/TrEMBL
    A0ACI8R2W3

  2. XM_054370979.1 → XP_054226954.1  serine dehydratase-like isoform X2

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0ACI8R2W3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GA7.1 GenPept UniProtKB/Swiss-Prot:Q96GA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous