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CYP2U1 cytochrome P450 family 2 subfamily U member 1 [ Homo sapiens (human) ]

Gene ID: 113612, updated on 1-Aug-2020

Summary

Official Symbol
CYP2U1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily U member 1provided by HGNC
Primary source
HGNC:HGNC:20582
See related
Ensembl:ENSG00000155016 MIM:610670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG49; SPG56; P450TEC
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 5.8), ovary (RPKM 5.2) and 24 other tissues See more
Orthologs

Genomic context

See CYP2U1 in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (107931549..107953461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108852716..108874617)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Neighboring gene sphingomyelin synthase 2 Neighboring gene CYP2U1 and SGMS2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 733, pseudogene Neighboring gene uncharacterized LOC107986298 Neighboring gene uncharacterized LOC107986299 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene LEF1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
omega-hydroxylase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2U1
Names
cytochrome P450, family 2, subfamily U, polypeptide 1
long-chain fatty acid omega-monooxygenase
spastic paraplegia 49
spastic paraplegia 56 (autosomal dominant)
NP_898898.1
XP_005262774.1
XP_005262777.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007961.1 RefSeqGene

    Range
    4989..26901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_183075.3NP_898898.1  cytochrome P450 2U1

    See identical proteins and their annotated locations for NP_898898.1

    Status: REVIEWED

    Source sequence(s)
    AC096564, AC114733, AK026498, AY343323, BU838483, BX354124, BX437421, CD672608
    Consensus CDS
    CCDS34047.1
    UniProtKB/Swiss-Prot
    Q7Z449
    Related
    ENSP00000333212.6, ENST00000332884.11
    Conserved Domains (1) summary
    pfam00067
    Location:60537
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    107931549..107953461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262717.2XP_005262774.1  cytochrome P450 2U1 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:60555
    p450; Cytochrome P450
  2. XM_005262720.2XP_005262777.1  cytochrome P450 2U1 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:164325
    p450; Cytochrome P450
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