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CYP2U1 cytochrome P450 family 2 subfamily U member 1 [ Homo sapiens (human) ]

Gene ID: 113612, updated on 23-May-2018
Official Symbol
CYP2U1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily U member 1provided by HGNC
Primary source
HGNC:HGNC:20582
See related
Ensembl:ENSG00000155016 MIM:610670; Vega:OTTHUMG00000161084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG49; SPG56; P450TEC
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 5.8), ovary (RPKM 5.2) and 24 other tissues See more
Orthologs
See CYP2U1 in Genome Data Viewer
Location:
4q25
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (107931549..107953461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108852716..108874617)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Neighboring gene uncharacterized LOC101929595 Neighboring gene sphingomyelin synthase 2 Neighboring gene RNA, U6 small nuclear 733, pseudogene Neighboring gene uncharacterized LOC107986298 Neighboring gene uncharacterized LOC107986299 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene LEF1 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 2U1
Names
cytochrome P450, family 2, subfamily U, polypeptide 1
spastic paraplegia 49
NP_898898.1
XP_005262774.1
XP_005262777.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007961.1 RefSeqGene

    Range
    5001..26897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_183075.2NP_898898.1  cytochrome P450 2U1

    See identical proteins and their annotated locations for NP_898898.1

    Status: REVIEWED

    Source sequence(s)
    AK026498, AY343323, BU838483, BX354124, BX437421, CD672608
    Consensus CDS
    CCDS34047.1
    UniProtKB/Swiss-Prot
    Q7Z449
    Related
    ENSP00000333212.6, OTTHUMP00000219686, ENST00000332884.10, OTTHUMT00000363691
    Conserved Domains (1) summary
    pfam00067
    Location:60537
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    107931549..107953461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262717.2XP_005262774.1  cytochrome P450 2U1 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:60555
    p450; Cytochrome P450
  2. XM_005262720.2XP_005262777.1  cytochrome P450 2U1 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:164325
    p450; Cytochrome P450
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