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CMTM1 CKLF like MARVEL transmembrane domain containing 1 [ Homo sapiens (human) ]

Gene ID: 113540, updated on 8-Jul-2018
Official Symbol
CMTM1provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 1provided by HGNC
Primary source
HGNC:HGNC:19172
See related
Ensembl:ENSG00000089505 MIM:607884; Vega:OTTHUMG00000137502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFH; CKLFH1; CKLFSF1
Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]
Expression
Biased expression in testis (RPKM 16.1), spleen (RPKM 1.5) and 1 other tissue See more
Orthologs
See CMTM1 in Genome Data Viewer
Location:
16q21
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (66566391..66579135)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66599849..66613038)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene thymidine kinase 2, mitochondrial Neighboring gene CKLF-CMTM1 readthrough Neighboring gene chemokine like factor Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene CKLF like MARVEL transmembrane domain containing 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough CKLF-CMTM1

Readthrough gene: CKLF-CMTM1, Included gene: CKLF

Homology

Clone Names

  • MGC71870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 1
Names
chemokine-like factor super family 1
chemokine-like factor superfamily 1
chemokine-like factor superfamily member 1
chemokine-like factor-like protein CKLFH1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052999.3NP_443725.3  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 13

    See identical proteins and their annotated locations for NP_443725.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) encodes the longest isoform (13).
    Source sequence(s)
    AY174119, BC057852, DN992496
    Consensus CDS
    CCDS10812.2
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000368814.2, OTTHUMP00000174787, ENST00000379500.6, OTTHUMT00000268809
    Conserved Domains (1) summary
    cl04571
    Location:131216
    MARVEL; Membrane-associating domain
  2. NM_181268.2NP_851785.2  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks an exon segment, compared to variant 17, which results in a translational frameshift in the last coding exon. The encoded isoform (14) is shorter and contains a distinct C-terminus, compared to the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174119, BC057852, DN992496
    Consensus CDS
    CCDS45504.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    UniProtKB/TrEMBL
    E9PAX0
    Related
    ENSP00000330061.6, OTTHUMP00000235187, ENST00000328020.10, OTTHUMT00000393193
    Conserved Domains (1) summary
    cl04571
    Location:131216
    MARVEL; Membrane-associating domain
  3. NM_181269.2NP_851786.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_851786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame segment of the first coding exon, compared to variant 17. The encoded isoform (1) is shorter than the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174118, DN992496
    Consensus CDS
    CCDS45503.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000405729.2, OTTHUMP00000233285, ENST00000457188.6, OTTHUMT00000390261
    Conserved Domains (1) summary
    cl14876
    Location:298
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  4. NM_181270.2NP_851787.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_851787.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 17, one of which results in a translational frameshift in the last coding exon. The encoded isoform (2) is shorter and contains a distinct C-terminus, compared to the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174119, DN992496
    Consensus CDS
    CCDS54019.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000432398.1, OTTHUMP00000233277, ENST00000528324.5, OTTHUMT00000390249
    Conserved Domains (1) summary
    cl14876
    Location:298
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  5. NM_181271.2NP_851788.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_851788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 17. The encoded isoform (3) is shorter than the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174120, DN992496
    Consensus CDS
    CCDS10810.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000331428.7, OTTHUMP00000174788, ENST00000332695.11, OTTHUMT00000268810
  6. NM_181272.2NP_851789.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_851789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' coding region, compared to variant 17. The encoded isoform (4) is shorter than the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174121, DN992496
    Consensus CDS
    CCDS10811.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000337119.6, OTTHUMP00000174789, ENST00000336328.10, OTTHUMT00000268813
  7. NM_181283.2NP_851800.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 5

    See identical proteins and their annotated locations for NP_851800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 17, one of which results in a translational frameshift in the last coding exon. The encoded isoform (5) is shorter and contains a distinct C-terminus, compared to the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174122, DN992496
    Consensus CDS
    CCDS54020.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000432687.1, OTTHUMP00000233280, ENST00000531885.5, OTTHUMT00000390255
  8. NM_181296.2NP_851813.1  CKLF-like MARVEL transmembrane domain-containing protein 1 isoform 12

    See identical proteins and their annotated locations for NP_851813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) has multiple differences in the coding region, compared to variant 17, one of which results in a translational frameshift in the last coding exon. The encoded isoform (12) is shorter and contains a distinct C-terminus, compared to the protein (isoform 13) encoded by variant 17.
    Source sequence(s)
    AY174133, DN992496
    Consensus CDS
    CCDS54021.1
    UniProtKB/Swiss-Prot
    Q8IZ96
    Related
    ENSP00000435020.1, OTTHUMP00000233286, ENST00000533666.5, OTTHUMT00000390262

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    66566391..66579135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181285.1: Suppressed sequence

    Description
    NM_181285.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_181286.1: Suppressed sequence

    Description
    NM_181286.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_181287.1: Suppressed sequence

    Description
    NM_181287.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_181288.1: Suppressed sequence

    Description
    NM_181288.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  5. NM_181289.2: Suppressed sequence

    Description
    NM_181289.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  6. NM_181290.1: Suppressed sequence

    Description
    NM_181290.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  7. NM_181292.1: Suppressed sequence

    Description
    NM_181292.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  8. NM_181293.1: Suppressed sequence

    Description
    NM_181293.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  9. NM_181294.1: Suppressed sequence

    Description
    NM_181294.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  10. NM_181295.1: Suppressed sequence

    Description
    NM_181295.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  11. NM_181297.1: Suppressed sequence

    Description
    NM_181297.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  12. NM_181298.1: Suppressed sequence

    Description
    NM_181298.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  13. NM_181299.1: Suppressed sequence

    Description
    NM_181299.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  14. NM_181300.1: Suppressed sequence

    Description
    NM_181300.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  15. NM_181301.1: Suppressed sequence

    Description
    NM_181301.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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