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TUBA3D tubulin alpha 3d [ Homo sapiens (human) ]

Gene ID: 113457, updated on 18-Aug-2020

Summary

Official Symbol
TUBA3Dprovided by HGNC
Official Full Name
tubulin alpha 3dprovided by HGNC
Primary source
HGNC:HGNC:24071
See related
Ensembl:ENSG00000075886 MIM:617878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KTCN9; TUBA2; H2-ALPHA
Summary
This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle formation during mitosis. [provided by RefSeq, Oct 2011]
Expression
Restricted expression toward testis (RPKM 122.6) See more
Orthologs

Genomic context

See TUBA3D in Genome Data Viewer
Location:
2q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (131476119..131482934)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (132233580..132240507)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 2 Neighboring gene ras homolog family member Q pseudogene 2 Neighboring gene mitotic spindle organizing protein 2A Neighboring gene microRNA 4784 Neighboring gene sphingomyelin phosphodiesterase 4B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
integrase gag-pol Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tubulin alpha-3D chain
Names
Alpha-tubulin 3C
Tubulin alpha-3C chain
alpha-tubulin 3D
alpha-tubulin isotype H2-alpha
tubulin alpha-2 chain
tubulin alpha-3C/D chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030320.1 RefSeqGene

    Range
    5113..11928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080386.4NP_525125.2  tubulin alpha-3D chain

    See identical proteins and their annotated locations for NP_525125.2

    Status: REVIEWED

    Source sequence(s)
    AK292253, BC057810, DB051220
    Consensus CDS
    CCDS33290.1
    UniProtKB/Swiss-Prot
    Q13748
    UniProtKB/TrEMBL
    Q1ZYQ1
    Related
    ENSP00000326042.6, ENST00000321253.7
    Conserved Domains (1) summary
    PTZ00335
    Location:1440
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    131476119..131482934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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