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DERPC DERPC proline and glycine rich nuclear protein [ Homo sapiens (human) ]

Gene ID: 113455421, updated on 21-Mar-2023

Summary

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Official Symbol
DERPCprovided by HGNC
Official Full Name
DERPC proline and glycine rich nuclear proteinprovided by HGNC
Primary source
HGNC:HGNC:54084
See related
Ensembl:ENSG00000286140 AllianceGenome:HGNC:54084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See DERPC in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69118010..69132588, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74914320..74928895, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69151913..69166491, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene hyaluronan synthase 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene UTP4 small subunit processome component Neighboring gene Sharpr-MPRA regulatory region 12307

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors. Sun M, et al. Mol Med, 2002 Oct. PMID 12477976, Free PMC Article
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. Zhou H, et al. J Proteome Res, 2013 Jan 4. PMID 23186163
  3. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast. Green AR, et al. Breast Cancer Res Treat, 2009 Jan. PMID 18213475
  4. Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease. Bigaud E, et al. Mol Cell Proteomics, 2016 May. PMID 26819315, Free PMC Article
  5. A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. Shiomi Y, et al. J Biol Chem, 2007 Jul 20. PMID 17545166

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. decreased expression of DERPC may be implicated in tumorigenesis of prostate and renal tumors
    Title: A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

Clone Names

  • FLJ20400, DKFZp434K0218

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
decreased expression in renal and prostate cancer protein
Names
Protein DERPC
chromosome transmission fidelity protein 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002847.4 → NP_001002847.1  decreased expression in renal and prostate cancer protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS92188.1
    UniProtKB/TrEMBL
    L0R4W3
    Related
    ENSP00000427718.2, ENST00000519520.7
    Conserved Domains (1) summary
    PHA03247
    Location:69 → 512
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001040144.3 → NP_001035234.2  decreased expression in renal and prostate cancer protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS92188.1
    UniProtKB/TrEMBL
    L0R4W3
    Conserved Domains (1) summary
    PHA03247
    Location:69 → 512
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001366602.2 → NP_001353531.1  decreased expression in renal and prostate cancer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009027

  4. NM_001366603.2 → NP_001353532.1  decreased expression in renal and prostate cancer protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS92188.1
    UniProtKB/TrEMBL
    L0R4W3
    Conserved Domains (1) summary
    PHA03247
    Location:69 → 512
    PHA03247; large tegument protein UL36; Provisional

  5. NM_001366604.2 → NP_001353533.1  decreased expression in renal and prostate cancer protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS92188.1
    UniProtKB/TrEMBL
    L0R4W3
    Related
    ENSP00000305687.6, ENST00000306585.9
    Conserved Domains (1) summary
    PHA03247
    Location:69 → 512
    PHA03247; large tegument protein UL36; Provisional

  6. NM_001366605.2 → NP_001353534.1  decreased expression in renal and prostate cancer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009027

  7. NM_001366606.2 → NP_001353535.1  decreased expression in renal and prostate cancer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009027

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69118010..69132588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    74914320..74928895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG12.1 GenPept UniProtKB/Swiss-Prot:P0CG12

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials