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EXOSC8 exosome component 8 [ Homo sapiens (human) ]

Gene ID: 11340, updated on 4-Oct-2020

Summary

Official Symbol
EXOSC8provided by HGNC
Official Full Name
exosome component 8provided by HGNC
Primary source
HGNC:HGNC:17035
See related
Ensembl:ENSG00000120699 MIM:606019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p9; CIP3; EAP2; OIP2; PCH1C; RRP43; Rrp43p; bA421P11.3
Summary
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in testis (RPKM 16.7), lymph node (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See EXOSC8 in Genome Data Viewer
Location:
13q13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (37000373..37009614)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37574678..37583751)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 5 Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene uncharacterized LOC105370165 Neighboring gene SPT20 homolog, SAGA complex component Neighboring gene casein kinase 1 alpha 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome complex component RRP43
Names
CBP-interacting protein 3
OIP-2
Opa interacting protein 2
exosome complex exonuclease RRP43
ribosomal RNA-processing protein 43
NP_852480.1
XP_006719826.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042275.1 RefSeqGene

    Range
    5246..14074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181503.3NP_852480.1  exosome complex component RRP43

    See identical proteins and their annotated locations for NP_852480.1

    Status: REVIEWED

    Source sequence(s)
    AL138706, BC020773, BU687776
    Consensus CDS
    CCDS31958.1
    UniProtKB/Swiss-Prot
    Q96B26
    Related
    ENSP00000374354.3, ENST00000389704.4
    Conserved Domains (1) summary
    cd11369
    Location:6266
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    37000373..37009614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719763.1XP_006719826.1  exosome complex component RRP43 isoform X1

    Conserved Domains (2) summary
    cd11369
    Location:56303
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome
    PRK04282
    Location:60309
    PRK04282; exosome complex RNA-binding protein Rrp42; Provisional

RNA

  1. XR_941480.1 RNA Sequence

  2. XR_429212.2 RNA Sequence

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