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OIP5 Opa interacting protein 5 [ Homo sapiens (human) ]

Gene ID: 11339, updated on 17-Jun-2019

Summary

Official Symbol
OIP5provided by HGNC
Official Full Name
Opa interacting protein 5provided by HGNC
Primary source
HGNC:HGNC:20300
See related
Ensembl:ENSG00000104147 MIM:606020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT86; MIS18B; LINT-25; MIS18beta; hMIS18beta; 5730547N13Rik
Summary
The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 12.1), bone marrow (RPKM 3.3) and 11 other tissues See more
Orthologs

Genomic context

See OIP5 in Genome Data Viewer
Location:
15q15.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41309268..41332621, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41601466..41624819, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene calcineurin like EF-hand protein 1 Neighboring gene OIP5 antisense RNA 1 Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
cell communication NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein Mis18-beta
Names
LAP2alpha interactor-25
MIS18 kinetochore protein homolog B
cancer/testis antigen 86
opa-interacting protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317860.1NP_001304789.1  protein Mis18-beta isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW406383, BC015050
    UniProtKB/Swiss-Prot
    O43482
    Related
    ENSP00000452851.1, ENST00000560640.1
    Conserved Domains (1) summary
    pfam03226
    Location:76130
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
  2. NM_007280.2NP_009211.1  protein Mis18-beta isoform 1

    See identical proteins and their annotated locations for NP_009211.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC015050
    Consensus CDS
    CCDS10074.1
    UniProtKB/Swiss-Prot
    O43482
    UniProtKB/TrEMBL
    A0A024R9N0
    Related
    ENSP00000220514.3, ENST00000220514.8
    Conserved Domains (1) summary
    pfam03226
    Location:76175
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41309268..41332621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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