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OIP5 Opa interacting protein 5 [ Homo sapiens (human) ]

Gene ID: 11339, updated on 6-Jul-2026
Official Symbol
OIP5provided by HGNC
Official Full Name
Opa interacting protein 5provided by HGNC
Primary source
HGNC:HGNC:20300
See related
Ensembl:ENSG00000104147 MIM:606020; AllianceGenome:HGNC:20300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT86; MIS18B; LINT-25; MIS18beta; hMIS18beta; 5730547N13Rik
Summary
The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 12.1), bone marrow (RPKM 3.3) and 11 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See OIP5 in Genome Data Viewer
Location:
15q15.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41309273..41332591, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39115437..39138755, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41601471..41624789, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9278 Neighboring gene MPRA-validated peak2306 silencer Neighboring gene calcineurin like EF-hand protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41575083-41575824 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:41577309-41578048 Neighboring gene OIP5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41628937-41629558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41629559-41630180 Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:41675757-41676295 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. Chun HK, et al. BMB Rep, 2010 May. PMID 20510019
  2. Opa interacting protein 5 promotes metastasis of nasopharyngeal carcinoma cells by promoting EMT via modulation of JAK2/STAT3 signal. Zheng YQ, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720169
  3. Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Li Y, et al. Oncol Rep, 2019 Apr. PMID 30816485, Free PMC Article
  4. OIP5 Expression Sensitize Glioblastoma Cells to Lomustine Treatment. Rodrigues-Junior DM, et al. J Mol Neurosci, 2018 Nov. PMID 30284228
  5. Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer. Kim TW, et al. Tumour Biol, 2017 Oct. PMID 29034772

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-TrCP-Mediated Proteolysis of Mis18beta Prevents Mislocalization of CENP-A and Chromosomal Instability.
    Title: β-TrCP-Mediated Proteolysis of Mis18β Prevents Mislocalization of CENP-A and Chromosomal Instability.
  2. [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and induces apoptosis of nasal epithelial cells in allergic rhinitis through up-regulation of TLR4].
    Title: [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and induces apoptosis of nasal epithelial cells in allergic rhinitis through up-regulation of TLR4].
  3. The role of OIP5 in the carcinogenesis and progression of ovarian cancer.
    Title: The role of OIP5 in the carcinogenesis and progression of ovarian cancer.
  4. Opa interacting protein 5 promotes proliferation and migration of trophoblast cells via activating STAT3 pathway.
    Title: Opa interacting protein 5 promotes proliferation and migration of trophoblast cells via activating STAT3 pathway.
  5. Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer.
    Title: Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer.
  6. Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer.
    Title: Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer.
  7. OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma.
    Title: OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma.
  8. Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor kappaB axis.
    Title: Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis.
  9. Long Non-Coding RNA OIP5-AS1 Inhibits the Proliferation and Migration of Esophageal Squamous Carcinoma Cells by Targeting FOXD1/miR-30a-5p Axis and the Effect of Micro- and Nano-Particles on Targeting Transfection System.
    Title: Long Non-Coding RNA OIP5-AS1 Inhibits the Proliferation and Migration of Esophageal Squamous Carcinoma Cells by Targeting FOXD1/miR-30a-5p Axis and the Effect of Micro- and Nano-Particles on Targeting Transfection System.
  10. LncRNA OIP5-AS1 affects the biological behaviors of chondrocytes of patients with osteoarthritis by regulating micro-30a-5p.
    Title: LncRNA OIP5-AS1 affects the biological behaviors of chondrocytes of patients with osteoarthritis by regulating micro-30a-5p.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CENP-A containing chromatin assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell communication NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CENP-A recruiting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromocenter IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein Mis18-beta
Names
LAP2alpha interactor-25
MIS18 kinetochore protein homolog B
cancer/testis antigen 86
opa-interacting protein 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317860.2 → NP_001304789.1  protein Mis18-beta isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW406383, BC015050
    UniProtKB/TrEMBL
    H0YKL4
    Related
    ENSP00000452851.1, ENST00000560640.1
    Conserved Domains (1) summary
    pfam03226
    Location:76 → 130
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

  2. NM_007280.2 → NP_009211.1  protein Mis18-beta isoform 1

    See identical proteins and their annotated locations for NP_009211.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC015050
    Consensus CDS
    CCDS10074.1
    UniProtKB/Swiss-Prot
    O43482, Q96BX7
    UniProtKB/TrEMBL
    A0ACI8SJ12
    Related
    ENSP00000220514.3, ENST00000220514.8
    Conserved Domains (1) summary
    pfam03226
    Location:76 → 175
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41309273..41332591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39115437..39138755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43482.2 GenPept UniProtKB/Swiss-Prot:O43482

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