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GABARAP GABA type A receptor-associated protein [ Homo sapiens (human) ]

Gene ID: 11337, updated on 9-Feb-2020

Summary

Official Symbol
GABARAPprovided by HGNC
Official Full Name
GABA type A receptor-associated proteinprovided by HGNC
Primary source
HGNC:HGNC:4067
See related
Ensembl:ENSG00000170296 MIM:605125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MM46; ATG8A; GABARAP-a
Summary
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 212.0), ovary (RPKM 206.1) and 25 other tissues See more
Orthologs

Genomic context

See GABARAP in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7240008..7242449, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7143738..7145753, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene PHD finger protein 23 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GABA(A) receptor-associated protein (GABARAP) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the mRNA expression of GABARAP in human mesenchymal stem cells PubMed
Tat tat HIV-1 Tat activates a CaMKII pathway at inhibitory synapses that leads to structural changes in GABARAP, resulting in increased membrane insertion of the gamma 2 subunit of GABAR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25768, MGC120154, MGC120155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GABA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome maturation TAS
Traceable Author Statement
more info
 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
protein targeting TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome membrane TAS
Traceable Author Statement
more info
 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid receptor-associated protein
Names
GABA(A) receptor-associated protein
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007278.2NP_009209.1  gamma-aminobutyric acid receptor-associated protein

    See identical proteins and their annotated locations for NP_009209.1

    Status: REVIEWED

    Source sequence(s)
    AC120057, AF067171
    Consensus CDS
    CCDS11092.1
    UniProtKB/Swiss-Prot
    O95166
    UniProtKB/TrEMBL
    Q6IAW1
    Related
    ENSP00000306866.5, ENST00000302386.10
    Conserved Domains (1) summary
    cd17232
    Location:2116
    Ubl_ATG8_GABARAP; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7240008..7242449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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