U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CTRC chymotrypsin C [ Homo sapiens (human) ]

Gene ID: 11330, updated on 2-Nov-2024

Summary

Official Symbol
CTRCprovided by HGNC
Official Full Name
chymotrypsin Cprovided by HGNC
Primary source
HGNC:HGNC:2523
See related
Ensembl:ENSG00000162438 MIM:601405; AllianceGenome:HGNC:2523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLCR; ELA4
Summary
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward pancreas (RPKM 2413.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CTRC in Genome Data Viewer
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (15438443..15449242)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (14883158..14893965)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15764939..15775737)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene uncharacterized LOC124903851 Neighboring gene FHAD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 234 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:15678468-15679667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15691409-15691909 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15710597-15711244 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15711245-15711892 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:15723563-15723730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15736144-15737006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 302 Neighboring gene EFHD2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15742803-15743302 Neighboring gene Sharpr-MPRA regulatory region 12140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15752556-15753456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15753457-15754355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15757008-15757508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15760169-15760668 Neighboring gene EF-hand domain family member D2 Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin like elastase 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15809342-15809842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15809843-15810343 Neighboring gene chymotrypsin like elastase 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chymotrypsin-C
Names
caldecrin
chymotrypsinogen C
elastase 4
elastase IV
serum calcium decreasing factor
NP_009203.2
XP_011538852.1
XP_054190022.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009253.2 RefSeqGene

    Range
    5002..15801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007272.3NP_009203.2  chymotrypsin-C preproprotein

    See identical proteins and their annotated locations for NP_009203.2

    Status: REVIEWED

    Source sequence(s)
    AL031283, BC015118, S82198
    Consensus CDS
    CCDS156.1
    UniProtKB/Swiss-Prot
    A8K082, O00765, Q99895, Q9NUH5
    Related
    ENSP00000365116.4, ENST00000375949.5
    Conserved Domains (1) summary
    cd00190
    Location:30265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    15438443..15449242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540550.2XP_011538852.1  chymotrypsin-C isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:29163
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    14883158..14893965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334047.1XP_054190022.1  chymotrypsin-C isoform X1