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CHRM5 cholinergic receptor muscarinic 5 [ Homo sapiens (human) ]

Gene ID: 1133, updated on 11-Jun-2021

Summary

Official Symbol
CHRM5provided by HGNC
Official Full Name
cholinergic receptor muscarinic 5provided by HGNC
Primary source
HGNC:HGNC:1954
See related
Ensembl:ENSG00000184984 MIM:118496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM5
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CHRM5 in Genome Data Viewer
Location:
15q14
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (33968497..34067458)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34260698..34359659)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RYR3 divergent transcript Neighboring gene ryanodine receptor 3 Neighboring gene complement C1q binding protein pseudogene 3 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene uncharacterized LOC107984748 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene ER membrane protein complex subunit 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC41838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
muscarinic acetylcholine receptor M5
Names
acetylcholine receptor, muscarinic 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320917.2NP_001307846.1  muscarinic acetylcholine receptor M5

    Status: VALIDATED

    Source sequence(s)
    AC009268, AC069045, BX102692
    Consensus CDS
    CCDS10031.1
    UniProtKB/Swiss-Prot
    P08912
    UniProtKB/TrEMBL
    A0A024R9I2
    Related
    ENSP00000453745.1, ENST00000557872.1
    Conserved Domains (2) summary
    pfam00001
    Location:47225
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40167
    7tm_4; Olfactory receptor
  2. NM_012125.4NP_036257.1  muscarinic acetylcholine receptor M5

    See identical proteins and their annotated locations for NP_036257.1

    Status: VALIDATED

    Source sequence(s)
    AC009268, AC069045, AK095198, BC041805
    Consensus CDS
    CCDS10031.1
    UniProtKB/Swiss-Prot
    P08912
    UniProtKB/TrEMBL
    A0A024R9I2, Q8IVW0
    Related
    ENSP00000372750.5, ENST00000383263.7
    Conserved Domains (2) summary
    pfam00001
    Location:47225
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40167
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    33968497..34067458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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