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STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

Gene ID: 11329, updated on 12-May-2019

Summary

Official Symbol
STK38provided by HGNC
Official Full Name
serine/threonine kinase 38provided by HGNC
Primary source
HGNC:HGNC:17847
See related
Ensembl:ENSG00000112079 MIM:606964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR; NDR1
Summary
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more
Orthologs

Genomic context

See STK38 in Genome Data Viewer
Location:
6p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (36493882..36547516, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461666..36515256, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 38
Names
NDR1 protein kinase
Ndr Ser/Thr kinase-like protein
nuclear Dbf2-related kinase 1
NP_001292031.1
NP_009202.1
XP_006715051.1
XP_006715052.1
XP_016865715.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305102.1NP_001292031.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_001292031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, BC095413, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208
    UniProtKB/TrEMBL
    A0A024RD18
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
  2. NM_007271.4NP_009202.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_009202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208
    UniProtKB/TrEMBL
    A0A024RD18
    Related
    ENSP00000229812.7, ENST00000229812.8
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    36493882..36547516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010226.1XP_016865715.1  serine/threonine-protein kinase 38 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:89382
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:87424
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006714988.4XP_006715051.1  serine/threonine-protein kinase 38 isoform X1

    See identical proteins and their annotated locations for XP_006715051.1

    UniProtKB/Swiss-Prot
    Q15208
    UniProtKB/TrEMBL
    A0A024RD18
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
  3. XM_006714989.4XP_006715052.1  serine/threonine-protein kinase 38 isoform X1

    See identical proteins and their annotated locations for XP_006715052.1

    UniProtKB/Swiss-Prot
    Q15208
    UniProtKB/TrEMBL
    A0A024RD18
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RNA

  1. XR_001743146.1 RNA Sequence

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