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STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

Gene ID: 11329, updated on 22-Sep-2022

Summary

Official Symbol
STK38provided by HGNC
Official Full Name
serine/threonine kinase 38provided by HGNC
Primary source
HGNC:HGNC:17847
See related
Ensembl:ENSG00000112079 MIM:606964; AllianceGenome:HGNC:17847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR; NDR1
Summary
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

See STK38 in Genome Data Viewer
Location:
6p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36493892..36547479, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36314555..36368143, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461669..36515256, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 38
Names
NDR1 protein kinase
Ndr Ser/Thr kinase-like protein
nuclear Dbf2-related kinase 1
NP_001292031.1
NP_009202.1
XP_016865715.1
XP_047274095.1
XP_047274096.1
XP_047274097.1
XP_047274098.1
XP_047274099.1
XP_047274100.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305102.2NP_001292031.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_001292031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, BC095413, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208, Q503A1
    UniProtKB/TrEMBL
    A0A024RD18
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
  2. NM_007271.4NP_009202.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_009202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208, Q503A1
    UniProtKB/TrEMBL
    A0A024RD18
    Related
    ENSP00000229812.7, ENST00000229812.8
    Conserved Domains (1) summary
    cd05628
    Location:87462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36493892..36547479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010226.2XP_016865715.1  serine/threonine-protein kinase 38 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:89382
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:87424
    PKc_like; Protein Kinases, catalytic domain
  2. XM_047418142.1XP_047274098.1  serine/threonine-protein kinase 38 isoform X2

  3. XM_047418140.1XP_047274096.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q503A1
    UniProtKB/TrEMBL
    A0A024RD18
  4. XM_047418143.1XP_047274099.1  serine/threonine-protein kinase 38 isoform X2

  5. XM_047418141.1XP_047274097.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q503A1
    UniProtKB/TrEMBL
    A0A024RD18
  6. XM_047418139.1XP_047274095.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q503A1
    UniProtKB/TrEMBL
    A0A024RD18
  7. XM_047418144.1XP_047274100.1  serine/threonine-protein kinase 38 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36314555..36368143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)