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FKBP9 FKBP prolyl isomerase 9 [ Homo sapiens (human) ]

Gene ID: 11328, updated on 1-Jun-2020

Summary

Official Symbol
FKBP9provided by HGNC
Official Full Name
FKBP prolyl isomerase 9provided by HGNC
Primary source
HGNC:HGNC:3725
See related
Ensembl:ENSG00000122642 MIM:616257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP60; FKBP63; PPIase
Expression
Ubiquitous expression in fat (RPKM 23.7), placenta (RPKM 21.9) and 24 other tissues See more
Orthologs

Genomic context

See FKBP9 in Genome Data Viewer
Location:
7p14.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (32957404..33006931)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (32997005..33046543)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 2 Neighboring gene RP9 pseudogene Neighboring gene RNA, U6 small nuclear 388, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IIIA Neighboring gene ribosomal protein S29 pseudogene 14 Neighboring gene RNA, 7SL, cytoplasmic 505, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126772, MGC138258, DKFZp586B1723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP9
Names
63 kDa FK506-binding protein
63 kDa FKBP
FK506 binding protein 9, 63 kDa
FK506-binding protein 9
FKBP-63
FKBP-9
PPIase FKBP9
rotamase
NP_001271270.1
NP_001271272.1
NP_009201.2
XP_011513417.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284341.1NP_001271270.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon in the 5' region compared to variant 1. The resulting isoform (2) is longer with an internal protein segment not found in isoform 1.
    Source sequence(s)
    AK300328, BC099918, CA427028, DA234297
    Consensus CDS
    CCDS64622.1
    UniProtKB/Swiss-Prot
    O95302
    UniProtKB/TrEMBL
    A7YQ73
    Related
    ENSP00000439250.1, ENST00000538336.5
    Conserved Domains (3) summary
    cd00051
    Location:550611
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:324415
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:548612
    EF-hand_7; EF-hand domain pair
  2. NM_001284343.1NP_001271272.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 3

    See identical proteins and their annotated locations for NP_001271272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK293440, BC099918, BQ688269, CA427028
    Consensus CDS
    CCDS64623.1
    UniProtKB/Swiss-Prot
    O95302
    UniProtKB/TrEMBL
    A7YQ73
    Related
    ENSP00000441317.1, ENST00000490776.3
    Conserved Domains (3) summary
    cd00051
    Location:265326
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:39130
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:263327
    EF-hand_7; EF-hand domain pair
  3. NM_007270.5NP_009201.2  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC099918, BC101723, DA234297
    Consensus CDS
    CCDS5439.1
    UniProtKB/Swiss-Prot
    O95302
    UniProtKB/TrEMBL
    A7YQ73
    Related
    ENSP00000242209.4, ENST00000242209.9
    Conserved Domains (2) summary
    cd00051
    Location:497558
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:47138
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    32957404..33006931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515115.3XP_011513417.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X1

    Conserved Domains (1) summary
    pfam00254
    Location:47138
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
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