U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IL4 interleukin 4 [ Ursus arctos (brown bear) ]

Gene ID: 113261716, updated on 15-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
IL4
Gene description
interleukin 4
See related
EnsemblRapid:ENSUARG00005007571
Gene type
protein coding
RefSeq status
MODEL
Organism
Ursus arctos
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IL4 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_06 current UrsArc2.0 (GCF_023065955.2) Unplaced Scaffold NW_026623067.1 (31149824..31157544)
102 previous assembly UrsArc1.0 (GCF_023065955.1) Unplaced Scaffold NW_025929617.1 (59573837..59581557, complement)

NW_026623067.1Genomic Context describing neighboring genes Neighboring gene RAD50 double strand break repair protein Neighboring gene interferon regulatory factor 1 Neighboring gene interleukin 5 Neighboring gene kinesin family member 3A Neighboring gene uncharacterized LOC113261490

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
interleukin-4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_023065955.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UrsArc2.0 Primary Assembly

Genomic

  1. NW_026623067.1 Reference UrsArc2.0 Primary Assembly

    Range
    31149824..31157544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026507950.3 → XP_026363735.1  interleukin-4

    Related
    ENSUARP00005011352.1
    Conserved Domains (1) summary
    pfam00727
    Location:28 → 130
    IL4; Interleukin 4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.