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LARP4 La ribonucleoprotein 4 [ Homo sapiens (human) ]

Gene ID: 113251, updated on 5-Sep-2021

Summary

Official Symbol
LARP4provided by HGNC
Official Full Name
La ribonucleoprotein 4provided by HGNC
Primary source
HGNC:HGNC:24320
See related
Ensembl:ENSG00000161813 MIM:618657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP13296
Expression
Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See LARP4 in Genome Data Viewer
Location:
12q13.12
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (50400862..50480004)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50794668..50873787)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984505 Neighboring gene KIAA1586 pseudogene Neighboring gene family with sequence similarity 186 member A Neighboring gene ribosomal protein L26 pseudogene 33 Neighboring gene small nucleolar RNA, C/D box 133 Neighboring gene fragile site, folic acid type, rare, fra(12)(q13.1) Neighboring gene disco interacting protein 2 homolog B Neighboring gene RNA, U6 small nuclear 769, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74631, DKFZp686E039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in posttranscriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
la-related protein 4
Names
La ribonucleoprotein domain family member 4
c-Mpl binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170803.2NP_001164274.1  la-related protein 4 isoform d

    See identical proteins and their annotated locations for NP_001164274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    AC090058
    UniProtKB/TrEMBL
    Q6P4E2, Q8TBL5
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199269
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001170804.2NP_001164275.1  la-related protein 4 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (e) has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC090058, AW002420, AY004310, BC063479, DB061954
    Consensus CDS
    CCDS53789.1
    UniProtKB/TrEMBL
    Q6P4E2, Q96J85
    Related
    ENSP00000429781.1, ENST00000522085.5
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  3. NM_001170808.2NP_001164279.1  la-related protein 4 isoform f

    See identical proteins and their annotated locations for NP_001164279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform f), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS53790.1
    UniProtKB/Swiss-Prot
    Q71RC2
    UniProtKB/TrEMBL
    Q6P4E2, Q8TBL5
    Related
    ENSP00000293618.8, ENST00000293618.12
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  4. NM_001330415.2NP_001317344.1  la-related protein 4 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform g), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS81690.1
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000415464.3, ENST00000429001.7
  5. NM_001352304.2NP_001339233.1  la-related protein 4 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 28, encodes isoform h.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS86300.1
    Related
    ENSP00000430851.1, ENST00000518561.5
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  6. NM_001352305.2NP_001339234.1  la-related protein 4 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:125199
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:204280
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  7. NM_001352306.2NP_001339235.1  la-related protein 4 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:207265
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. NM_001352307.2NP_001339236.1  la-related protein 4 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199257
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. NM_001352308.2NP_001339237.1  la-related protein 4 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:126200
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:205275
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. NM_001352309.2NP_001339238.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 14-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  11. NM_001352310.2NP_001339239.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  12. NM_001352311.2NP_001339240.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 13, 14, and 16-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  13. NM_001352312.2NP_001339241.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 13-15. 17, and 18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  14. NM_001352313.2NP_001339242.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 13-16 and 18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  15. NM_001352314.2NP_001339243.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 13-17, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  16. NM_001352315.2NP_001339244.1  la-related protein 4 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:119193
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:198268
    RRM_SF; RNA recognition motif (RRM) superfamily
  17. NM_001352316.2NP_001339245.1  la-related protein 4 isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform o.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129199
    RRM_SF; RNA recognition motif (RRM) superfamily
  18. NM_001352317.2NP_001339246.1  la-related protein 4 isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform o.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129199
    RRM_SF; RNA recognition motif (RRM) superfamily
  19. NM_001352318.2NP_001339247.1  la-related protein 4 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  20. NM_001352319.2NP_001339248.1  la-related protein 4 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:49123
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:128198
    RRM_SF; RNA recognition motif (RRM) superfamily
  21. NM_001352320.2NP_001339249.1  la-related protein 4 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129199
    RRM_SF; RNA recognition motif (RRM) superfamily
  22. NM_001352321.2NP_001339250.1  la-related protein 4 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  23. NM_001352322.2NP_001339251.1  la-related protein 4 isoform t

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199269
    RRM_SF; RNA recognition motif (RRM) superfamily
  24. NM_001352323.2NP_001339252.1  la-related protein 4 isoform u

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (3) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    pfam14179
    Location:292360
    YppG; YppG-like protein
  25. NM_001352324.2NP_001339253.1  la-related protein 4 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variant 7, encodes isoform h.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS86300.1
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  26. NM_001352325.2NP_001339254.1  la-related protein 4 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (3) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    pfam14179
    Location:292360
    YppG; YppG-like protein
  27. NM_001352326.2NP_001339255.1  la-related protein 4 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199269
    RRM_SF; RNA recognition motif (RRM) superfamily
  28. NM_052879.5NP_443111.4  la-related protein 4 isoform a

    See identical proteins and their annotated locations for NP_443111.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS41782.1
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000381490.2, ENST00000398473.7
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  29. NM_199188.3NP_954658.2  la-related protein 4 isoform b

    See identical proteins and their annotated locations for NP_954658.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS44879.2
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000429077.1, ENST00000518444.5
    Conserved Domains (2) summary
    cd08035
    Location:119193
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:198274
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  30. NM_199190.3NP_954660.1  la-related protein 4 isoform c

    See identical proteins and their annotated locations for NP_954660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS44880.1
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000340901.5, ENST00000347328.9
    Conserved Domains (2) summary
    cd08035
    Location:120194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199269
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    50400862..50480004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448827.1XP_024304595.1  la-related protein 4 isoform X11

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:207283
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  2. XM_024448825.1XP_024304593.1  la-related protein 4 isoform X9

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:207283
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  3. XM_011537836.3XP_011536138.1  la-related protein 4 isoform X4

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:207283
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  4. XM_024448826.1XP_024304594.1  la-related protein 4 isoform X10

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:207277
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_011537843.3XP_011536145.1  la-related protein 4 isoform X6

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:207277
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_017018757.1XP_016874246.1  la-related protein 4 isoform X7

    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129199
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011537835.3XP_011536137.1  la-related protein 4 isoform X3

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:207277
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_011537829.3XP_011536131.1  la-related protein 4 isoform X1

    Conserved Domains (2) summary
    cd08035
    Location:128202
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:207283
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  9. XM_017018754.2XP_016874243.1  la-related protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  10. XM_017018751.2XP_016874240.1  la-related protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  11. XM_011537838.3XP_011536140.1  la-related protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011536140.1

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  12. XM_017018753.2XP_016874242.1  la-related protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  13. XM_024448824.1XP_024304592.1  la-related protein 4 isoform X8

    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
  14. XM_024448823.1XP_024304591.1  la-related protein 4 isoform X2

    Conserved Domains (2) summary
    cd08035
    Location:50124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
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