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KIF12 kinesin family member 12 [ Homo sapiens (human) ]

Gene ID: 113220, updated on 3-Jun-2018
Official Symbol
KIF12provided by HGNC
Official Full Name
kinesin family member 12provided by HGNC
Primary source
HGNC:HGNC:21495
See related
Ensembl:ENSG00000136883 MIM:611278; Vega:OTTHUMG00000020533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]
Expression
Biased expression in kidney (RPKM 28.1), gall bladder (RPKM 9.6) and 9 other tissues See more
Orthologs
See KIF12 in Genome Data Viewer
Location:
9q32
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (114091623..114100090, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116853903..116861600, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987120 Neighboring gene alpha-1-microglobulin/bikunin precursor Neighboring gene uncharacterized LOC105376225 Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051222.1 RefSeqGene

    Range
    6028..13447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138424.1NP_612433.1  kinesin-like protein KIF12

    See identical proteins and their annotated locations for NP_612433.1

    Status: REVIEWED

    Source sequence(s)
    BC010626
    Consensus CDS
    CCDS6801.1
    UniProtKB/Swiss-Prot
    Q96FN5
    UniProtKB/TrEMBL
    B1ALC3
    Related
    ENSP00000363232.3, OTTHUMP00000021965, ENST00000374118.8, OTTHUMT00000053751
    Conserved Domains (2) summary
    cd00106
    Location:1225
    KISc; Kinesin motor domain
    cl26472
    Location:224330
    DUF3084; Protein of unknown function (DUF3084)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    114091623..114100090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251683.5XP_005251740.1  kinesin-like protein KIF12 isoform X2

    Conserved Domains (3) summary
    cd00106
    Location:25363
    KISc; Kinesin motor domain
    pfam00225
    Location:31365
    Kinesin; Kinesin motor domain
    pfam12711
    Location:383469
    Kinesin-relat_1; Kinesin motor
  2. XM_006716947.2XP_006717010.1  kinesin-like protein KIF12 isoform X4

    Conserved Domains (3) summary
    cd00106
    Location:8329
    KISc; Kinesin motor domain
    pfam00225
    Location:1331
    Kinesin; Kinesin motor domain
    pfam12711
    Location:349435
    Kinesin-relat_1; Kinesin motor
  3. XM_024447404.1XP_024303172.1  kinesin-like protein KIF12 isoform X1

    Conserved Domains (2) summary
    cd00106
    Location:1225
    KISc; Kinesin motor domain
    cl26472
    Location:224330
    DUF3084; Protein of unknown function (DUF3084)
  4. XM_024447408.1XP_024303176.1  kinesin-like protein KIF12 isoform X7

    Related
    ENSP00000491702.1, ENST00000640217.1
    Conserved Domains (2) summary
    cd00106
    Location:25363
    KISc; Kinesin motor domain
    cl26472
    Location:362468
    DUF3084; Protein of unknown function (DUF3084)
  5. XM_024447405.1XP_024303173.1  kinesin-like protein KIF12 isoform X3

    Conserved Domains (2) summary
    cd00106
    Location:1225
    KISc; Kinesin motor domain
    cl26472
    Location:224330
    DUF3084; Protein of unknown function (DUF3084)
  6. XM_024447406.1XP_024303174.1  kinesin-like protein KIF12 isoform X5

    Conserved Domains (2) summary
    cd00106
    Location:1225
    KISc; Kinesin motor domain
    cl26472
    Location:224330
    DUF3084; Protein of unknown function (DUF3084)
  7. XM_024447407.1XP_024303175.1  kinesin-like protein KIF12 isoform X6

    Conserved Domains (2) summary
    cl22853
    Location:1119
    Motor_domain; Myosin and Kinesin motor domain
    cl28271
    Location:137256
    dnaA; chromosomal replication initiation protein; Provisional

RNA

  1. XR_002956750.1 RNA Sequence

  2. XR_002956749.1 RNA Sequence

  3. XR_002956751.1 RNA Sequence

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