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GOLM2 golgi membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 113201, updated on 23-Nov-2021

Summary

Official Symbol
GOLM2provided by HGNC
Official Full Name
golgi membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:24892
See related
Ensembl:ENSG00000166734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H63; CASC4
Summary
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in thyroid (RPKM 38.2), adrenal (RPKM 35.0) and 25 other tissues See more
Orthologs
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Genomic context

See GOLM2 in Genome Data Viewer
Location:
15q15.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (44288719..44415758)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44580917..44707956)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene FERM domain containing 5 Neighboring gene ACTB pseudogene 7 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 55 Neighboring gene Sharpr-MPRA regulatory region 13790 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 43 Neighboring gene CTD small phosphatase like 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene 1 Neighboring gene EIF3J divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74708, DKFZp459F1927

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein GOLM2
Names
cancer susceptibility 4
cancer susceptibility candidate 4
cancer susceptibility candidate gene 4 protein
gene associated with HER-2/neu overexpression
protein CASC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138423.4NP_612432.2  protein GOLM2 isoform a

    See identical proteins and their annotated locations for NP_612432.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AL832840, BC012124, BI467176, DB229269
    Consensus CDS
    CCDS10108.1
    UniProtKB/Swiss-Prot
    Q6P4E1
    Related
    ENSP00000299957.6, ENST00000299957.11
    Conserved Domains (2) summary
    TIGR02168
    Location:42200
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl27123
    Location:169266
    Arch_fla_DE; Archaeal flagella protein
  2. NM_177974.3NP_816929.1  protein GOLM2 isoform b

    See identical proteins and their annotated locations for NP_816929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AC025043, AY358086, BC012124, BI467176, DB229269
    Consensus CDS
    CCDS10109.1
    UniProtKB/Swiss-Prot
    Q6P4E1
    Related
    ENSP00000335063.4, ENST00000345795.6
    Conserved Domains (1) summary
    cl19219
    Location:118193
    DUF342; Protein of unknown function (DUF342)

RNA

  1. NR_157849.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025043, AC090519

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    44288719..44415758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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