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CHST14 carbohydrate sulfotransferase 14 [ Homo sapiens (human) ]

Gene ID: 113189, updated on 3-Dec-2023

Summary

Official Symbol
CHST14provided by HGNC
Official Full Name
carbohydrate sulfotransferase 14provided by HGNC
Primary source
HGNC:HGNC:24464
See related
Ensembl:ENSG00000169105 MIM:608429; AllianceGenome:HGNC:24464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATCS; D4ST1; EDSMC1; HNK1ST
Summary
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Orthologs
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Genomic context

See CHST14 in Genome Data Viewer
Location:
15q15.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40470984..40473158)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38278334..38280508)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40763183..40765357)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40699201-40699700 Neighboring gene isovaleryl-CoA dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40728630-40729168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40729169-40729706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40731858-40732395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40733201-40733702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40733703-40734202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40737995-40738496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9243 Neighboring gene bromo adjacent homology domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9244 Neighboring gene uncharacterized LOC124903473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40755909-40756410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40756411-40756910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40764047-40764950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40781343-40781994 Neighboring gene ribosomal protein L9 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6337 Neighboring gene Sharpr-MPRA regulatory region 12089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9246 Neighboring gene coiled-coil domain containing 32 Neighboring gene RNA, U6 small nuclear 516, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
carbohydrate sulfotransferase 14
Names
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
carbohydrate (dermatan 4) sulfotransferase 14
dermatan 4 sulfotransferase 1
NP_569735.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017074.1 RefSeqGene

    Range
    5001..7198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_600

mRNA and Protein(s)

  1. NM_130468.4NP_569735.1  carbohydrate sulfotransferase 14

    See identical proteins and their annotated locations for NP_569735.1

    Status: REVIEWED

    Source sequence(s)
    AB066595, CR997569
    Consensus CDS
    CCDS10059.1
    UniProtKB/Swiss-Prot
    Q6PJ31, Q6UXA0, Q8NCH0, Q96P94
    UniProtKB/TrEMBL
    H0YN65
    Related
    ENSP00000307297.6, ENST00000306243.7
    Conserved Domains (1) summary
    pfam03567
    Location:144364
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40470984..40473158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38278334..38280508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)