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SCAMP4 secretory carrier membrane protein 4 [ Homo sapiens (human) ]

Gene ID: 113178, updated on 4-Jul-2021

Summary

Official Symbol
SCAMP4provided by HGNC
Official Full Name
secretory carrier membrane protein 4provided by HGNC
Primary source
HGNC:HGNC:30385
See related
Ensembl:ENSG00000227500 MIM:613764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCAMP-4
Summary
Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
Expression
Ubiquitous expression in prostate (RPKM 16.8), thyroid (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

See SCAMP4 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1905399..1926013)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1905398..1926012)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 17A, depalmitoylase Neighboring gene Sharpr-MPRA regulatory region 13932 Neighboring gene adenosine deaminase tRNA specific 3 Neighboring gene uncharacterized LOC105372238 Neighboring gene casein kinase 1 gamma 2 Neighboring gene CSNK1G2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33847, FLJ90105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
secretory carrier-associated membrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329539.2NP_001316468.1  secretory carrier-associated membrane protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC012615, AK074586, AK307641, BC062598, CA417608
    UniProtKB/Swiss-Prot
    Q969E2
    Conserved Domains (1) summary
    pfam04144
    Location:1134
    SCAMP; SCAMP family
  2. NM_001329540.2NP_001316469.1  secretory carrier-associated membrane protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC012615, AK092056, BC062598, CA417608
    Consensus CDS
    CCDS86689.1
    UniProtKB/Swiss-Prot
    Q969E2
    Related
    ENSP00000386865.1, ENST00000409472.5
    Conserved Domains (1) summary
    pfam04144
    Location:5145
    SCAMP; SCAMP family
  3. NM_079834.4NP_524558.1  secretory carrier-associated membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_524558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK074586, AL832731, BC062598, CA417608
    Consensus CDS
    CCDS45903.1
    UniProtKB/Swiss-Prot
    Q969E2
    Related
    ENSP00000316007.7, ENST00000316097.13
    Conserved Domains (1) summary
    pfam04144
    Location:5178
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1905399..1926013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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