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IZUMO4 IZUMO family member 4 [ Homo sapiens (human) ]

Gene ID: 113177, updated on 23-Nov-2021

Summary

Official Symbol
IZUMO4provided by HGNC
Official Full Name
IZUMO family member 4provided by HGNC
Primary source
HGNC:HGNC:26950
See related
Ensembl:ENSG00000099840 MIM:618897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf36; IMAGE:4215339
Expression
Restricted expression toward testis (RPKM 134.0) See more
Orthologs
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Genomic context

See IZUMO4 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2096669..2099590)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2096914..2099589)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.489 Neighboring gene MOB kinase activator 3A Neighboring gene adaptor related protein complex 3 subunit delta 1 Neighboring gene Sharpr-MPRA regulatory region 14448 Neighboring gene DOT1 like histone lysine methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
izumo sperm-egg fusion protein 4
Names
putative SAMP14 binding protein variant 1
putative SAMP14 binding protein variant 2
sperm 22 kDa protein c113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031735.3NP_001026905.2  izumo sperm-egg fusion protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame segment, compared to variant 3, resulting in a shorter protein (isoform 1) that has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AC005328, AW182303, BC014609, BX378854
    Consensus CDS
    CCDS35499.1
    UniProtKB/Swiss-Prot
    Q1ZYL8
    Related
    ENSP00000378718.2, ENST00000395307.6
    Conserved Domains (1) summary
    pfam15005
    Location:17158
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
  2. NM_001039846.2NP_001034935.1  izumo sperm-egg fusion protein 4 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001034935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer protein (isoform 3).
    Source sequence(s)
    AC005328, AW182303, BI827974, BX378854
    Consensus CDS
    CCDS42458.1
    UniProtKB/Swiss-Prot
    Q1ZYL8
    Related
    ENSP00000378712.3, ENST00000395301.8
    Conserved Domains (1) summary
    pfam15005
    Location:17158
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
  3. NM_001363588.2NP_001350517.1  izumo sperm-egg fusion protein 4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005328, AW182303, BC014609, BI828436
    Consensus CDS
    CCDS86690.1
    Related
    ENSP00000378709.2, ENST00000395296.5
    Conserved Domains (1) summary
    pfam15005
    Location:18158
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2096669..2099590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451342.1XP_024307110.1  izumo sperm-egg fusion protein 4 isoform X1

    Conserved Domains (1) summary
    pfam15005
    Location:65237
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
  2. XM_024451343.1XP_024307111.1  izumo sperm-egg fusion protein 4 isoform X2

    Conserved Domains (1) summary
    pfam15005
    Location:65237
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
  3. XM_024451344.1XP_024307112.1  izumo sperm-egg fusion protein 4 isoform X3

    Conserved Domains (1) summary
    pfam15005
    Location:65237
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated

RNA

  1. XR_002958248.1 RNA Sequence

    Related
    ENST00000478879.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_052878.1: Suppressed sequence

    Description
    NM_052878.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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