Format

Send to:

Choose Destination

CD300A CD300a molecule [ Homo sapiens (human) ]

Gene ID: 11314, updated on 7-Jun-2020

Summary

Official Symbol
CD300Aprovided by HGNC
Official Full Name
CD300a moleculeprovided by HGNC
Primary source
HGNC:HGNC:19319
See related
Ensembl:ENSG00000167851 MIM:606790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
Summary
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Broad expression in spleen (RPKM 24.5), appendix (RPKM 12.1) and 14 other tissues See more
Orthologs

Genomic context

See CD300A in Genome Data Viewer
Location:
17q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74466373..74484798)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72462509..72480937)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene CD300 molecule like family member b Neighboring gene uncharacterized LOC107985074 Neighboring gene CD300c molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of CD300a molecule (CD300A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NK T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of activation of Janus kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of eosinophil activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of eosinophil migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 8
Names
CD300 antigen-like family member A
CD300a antigen
CMRF35H leukocyte immunoglobulin-like receptor
NK inhibitory receptor
immunoglobulin superfamily member 12
inhibitory receptor protein 60
leukocyte membrane antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256841.2NP_001243770.1  CMRF35-like molecule 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001243770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2), also referred to as IRC1c, is shorter compared to isoform 1.
    Source sequence(s)
    AC079325, AJ010102, BF059016
    Consensus CDS
    CCDS58590.1
    UniProtKB/Swiss-Prot
    Q9UGN4
    Related
    ENSP00000308188.5, ENST00000310828.9
    Conserved Domains (1) summary
    pfam15330
    Location:86160
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
  2. NM_001330456.1NP_001317385.1  CMRF35-like molecule 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS82197.1
    UniProtKB/TrEMBL
    J3QKQ4
    Related
    ENSP00000497133.1, ENST00000648095.1
  3. NM_001330457.2NP_001317386.1  CMRF35-like molecule 8 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC079325
    Consensus CDS
    CCDS82196.1
    UniProtKB/Swiss-Prot
    Q9UGN4
    Related
    ENSP00000376401.3, ENST00000392625.7
  4. NM_007261.4NP_009192.2  CMRF35-like molecule 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1), also referred to as IRC1a.
    Source sequence(s)
    BC032352
    Consensus CDS
    CCDS32720.1
    UniProtKB/Swiss-Prot
    Q9UGN4
    Related
    ENSP00000353259.3, ENST00000360141.8
    Conserved Domains (3) summary
    cd05716
    Location:23117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22105
    IG_like; Immunoglobulin like
    pfam15330
    Location:199273
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74466373..74484798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256990.3XP_005257047.1  CMRF35-like molecule 8 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:23117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22105
    IG_like; Immunoglobulin like
  2. XM_005256991.5XP_005257048.1  CMRF35-like molecule 8 isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:23117
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22105
    IG_like; Immunoglobulin like
  3. XM_006721656.3XP_006721719.1  CMRF35-like molecule 8 isoform X3

    See identical proteins and their annotated locations for XP_006721719.1

    UniProtKB/TrEMBL
    J3QKQ4
    Related
    ENSP00000463189.1, ENST00000577511.1
    Conserved Domains (1) summary
    pfam15330
    Location:69143
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
Support Center