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Abcg1 ATP binding cassette subfamily G member 1 [ Mus musculus (house mouse) ]

Gene ID: 11307, updated on 5-Jan-2023

Summary

Official Symbol
Abcg1provided by MGI
Official Full Name
ATP binding cassette subfamily G member 1provided by MGI
Primary source
MGI:MGI:107704
See related
Ensembl:ENSMUSG00000024030 AllianceGenome:MGI:107704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abc8; White
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thymus adult (RPKM 31.5), lung adult (RPKM 23.3) and 16 other tissues See more
Orthologs
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Genomic context

See Abcg1 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31276668..31336958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31057694..31117984)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41562 Neighboring gene uromodulin-like 1 Neighboring gene trefoil factor 3, intestinal Neighboring gene trefoil factor 2 (spasmolytic protein 1)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141022

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type sterol transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to high density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipid ISO
Inferred from Sequence Orthology
more info
 
involved_in reverse cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family G member 1
Names
ATP-binding cassette 8
ATP-binding cassette transporter 8
ATP-binding cassette, sub-family G (WHITE), member 1
white protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009593.2NP_033723.1  ATP-binding cassette sub-family G member 1

    See identical proteins and their annotated locations for NP_033723.1

    Status: REVIEWED

    Source sequence(s)
    AC167247, AF323659, AK037433, BY296839, CO431055, CV558133
    Consensus CDS
    CCDS28602.1
    UniProtKB/Swiss-Prot
    Q64343
    UniProtKB/TrEMBL
    A0A6P5R9E6, A0A8C6GZC5, Q0VDW9
    Related
    ENSMUSP00000024829.7, ENSMUST00000024829.8
    Conserved Domains (1) summary
    TIGR00955
    Location:60666
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31276668..31336958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)