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Abca2 ATP-binding cassette, sub-family A (ABC1), member 2 [ Mus musculus (house mouse) ]

Gene ID: 11305, updated on 10-Oct-2019

Summary

Official Symbol
Abca2provided by MGI
Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 2provided by MGI
Primary source
MGI:MGI:99606
See related
Ensembl:ENSMUSG00000026944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abc2; AI413825; mKIAA1062; D2H0S1474E
Expression
Broad expression in genital fat pad adult (RPKM 51.2), cerebellum adult (RPKM 40.0) and 22 other tissues See more
Orthologs

Genomic context

See Abca2 in Genome Data Viewer
Location:
2 A3; 2 17.25 cM
Exon count:
50
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25428599..25448544)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (25284194..25304059)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene fucosyltransferase 7 Neighboring gene microRNA 3087 Neighboring gene non-homologous end joining factor Neighboring gene chloride intracellular channel 3 Neighboring gene prostaglandin D2 synthase (brain)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide-translocating ATPase activity ISO
Inferred from Sequence Orthology
more info
 
endopeptidase regulator activity ISO
Inferred from Sequence Orthology
more info
 
lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular sphingolipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ceramide translocation ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of low-density lipoprotein receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid precursor protein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
regulation of intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
regulation of post-translational protein modification ISO
Inferred from Sequence Orthology
more info
 
regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell periphery IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
sphingosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family A member 2
Names
ATP-binding cassette 2
ATP-binding cassette transporter 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368624.1NP_001355553.1  ATP-binding cassette sub-family A member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK169438, AL732557, CJ126415, CJ263864
    Conserved Domains (1) summary
    TIGR01257
    Location:12368
    rim_protein; retinal-specific rim ABC transporter
  2. NM_007379.3NP_031405.2  ATP-binding cassette sub-family A member 2 isoform 1

    See identical proteins and their annotated locations for NP_031405.2

    Status: VALIDATED

    Source sequence(s)
    AK169438, AL732557, CJ126415, CJ263864
    Consensus CDS
    CCDS15773.1
    UniProtKB/TrEMBL
    A2AJ26
    Related
    ENSMUSP00000099983.3, ENSMUST00000102919.3
    Conserved Domains (2) summary
    TIGR01257
    Location:12367
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20502273
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    25428599..25448544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246714.1XP_030102574.1  ATP-binding cassette sub-family A member 2 isoform X5

  2. XM_030246727.1XP_030102587.1  ATP-binding cassette sub-family A member 2 isoform X8

  3. XM_006497614.4XP_006497677.1  ATP-binding cassette sub-family A member 2 isoform X4

    Conserved Domains (2) summary
    TIGR01257
    Location:162356
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20392262
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
  4. XM_006497615.2XP_006497678.1  ATP-binding cassette sub-family A member 2 isoform X6

    Conserved Domains (2) summary
    TIGR01257
    Location:102350
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20332256
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
  5. XM_006497616.2XP_006497679.1  ATP-binding cassette sub-family A member 2 isoform X7

    Conserved Domains (2) summary
    TIGR01257
    Location:102349
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20322255
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
  6. XM_006497609.1XP_006497672.1  ATP-binding cassette sub-family A member 2 isoform X1

    Conserved Domains (2) summary
    TIGR01257
    Location:582398
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20812304
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
  7. XM_006497611.1XP_006497674.1  ATP-binding cassette sub-family A member 2 isoform X3

    Conserved Domains (2) summary
    TIGR01257
    Location:582379
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20622285
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
  8. XM_006497610.1XP_006497673.1  ATP-binding cassette sub-family A member 2 isoform X2

    Conserved Domains (2) summary
    TIGR01257
    Location:582397
    rim_protein; retinal-specific rim ABC transporter
    cd03263
    Location:20802303
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
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