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PLCD3 phospholipase C delta 3 [ Homo sapiens (human) ]

Gene ID: 113026, updated on 23-Nov-2021

Summary

Official Symbol
PLCD3provided by HGNC
Official Full Name
phospholipase C delta 3provided by HGNC
Primary source
HGNC:HGNC:9061
See related
Ensembl:ENSG00000161714 MIM:608795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLC-delta-3
Summary
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues See more
Orthologs
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Genomic context

See PLCD3 in Genome Data Viewer
Location:
17q21.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45108959..45132524, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43186327..43209882, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987243 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene N-myristoyltransferase 1 Neighboring gene microRNA 6784 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene HEXIM P-TEFb complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
PLC delta3
phosphoinositide phospholipase C-delta-3
NP_588614.1
XP_011522555.1
XP_024306322.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133373.5NP_588614.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

    See identical proteins and their annotated locations for NP_588614.1

    Status: REVIEWED

    Source sequence(s)
    AC002117, AL834392, BC072384, BU621728, HY169731
    Consensus CDS
    CCDS74077.1
    UniProtKB/Swiss-Prot
    Q8N3E9
    Related
    ENSP00000479636.1, ENST00000619929.5
    Conserved Domains (7) summary
    cd00275
    Location:660787
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08630
    Location:336631
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    PLN02228
    Location:255772
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:65181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:70170
    PH; PH domain
    pfam09279
    Location:255336
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:201250
    EF-hand_10; EF hand

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45108959..45132524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450554.1XP_024306322.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1

    Conserved Domains (4) summary
    cd00275
    Location:705832
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08630
    Location:336676
    PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3
    cd13363
    Location:65181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    cd16218
    Location:186324
    EFh_PI-PLCdelta3; EF-hand motif found in phosphoinositide phospholipase C delta 3 (PI-PLC-delta3)
  2. XM_011524253.3XP_011522555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2

    Conserved Domains (5) summary
    cd13363
    Location:65181
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:70170
    PH; PH domain
    pfam09279
    Location:255336
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:201250
    EF-hand_10; EF hand
    cl14615
    Location:336471
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
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