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VPS26B VPS26, retromer complex component B [ Homo sapiens (human) ]

Gene ID: 112936, updated on 8-Dec-2019

Summary

Official Symbol
VPS26Bprovided by HGNC
Official Full Name
VPS26, retromer complex component Bprovided by HGNC
Primary source
HGNC:HGNC:28119
See related
Ensembl:ENSG00000151502 MIM:610027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pep8b
Expression
Ubiquitous expression in brain (RPKM 21.5), skin (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See VPS26B in Genome Data Viewer
Location:
11q25
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (134224664..134247788)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (134094561..134117686)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene junctional adhesion molecule 3 Neighboring gene small nucleolar RNA, C/D box 153 Neighboring gene non-SMC condensin II complex subunit D3 Neighboring gene zinc finger protein 628 pseudogene Neighboring gene thymocyte nuclear protein 1 Neighboring gene acyl-CoA dehydrogenase family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10485

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retromer complex ISS
Inferred from Sequence or Structural Similarity
more info
 
retromer, cargo-selective complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
vacuolar protein sorting-associated protein 26B
Names
vesicle protein sorting 26B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052875.5NP_443107.1  vacuolar protein sorting-associated protein 26B

    See identical proteins and their annotated locations for NP_443107.1

    Status: VALIDATED

    Source sequence(s)
    AP000859, AV735504, BC007799, BC013255, BC014128, BC098386
    Consensus CDS
    CCDS8495.1
    UniProtKB/Swiss-Prot
    Q4G0F5
    UniProtKB/TrEMBL
    A0A024R3L9
    Related
    ENSP00000281187.5, ENST00000281187.10
    Conserved Domains (1) summary
    pfam03643
    Location:6281
    Vps26; Vacuolar protein sorting-associated protein 26

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    134224664..134247788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542565.3XP_011540867.1  vacuolar protein sorting-associated protein 26B isoform X1

    Conserved Domains (1) summary
    cl22903
    Location:6184
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
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