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PHF21B PHD finger protein 21B [ Homo sapiens (human) ]

Gene ID: 112885, updated on 23-Nov-2021

Summary

Official Symbol
PHF21Bprovided by HGNC
Official Full Name
PHD finger protein 21Bprovided by HGNC
Primary source
HGNC:HGNC:25161
See related
Ensembl:ENSG00000056487 MIM:616727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHF4; BHC80L
Expression
Biased expression in testis (RPKM 1.4), brain (RPKM 1.4) and 8 other tissues See more
Orthologs
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Genomic context

See PHF21B in Genome Data Viewer
Location:
22q13.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (44881162..45010005, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (45277042..45405886, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene PRR5-ARHGAP8 readthrough Neighboring gene Sharpr-MPRA regulatory region 7347 Neighboring gene proline rich 5 Neighboring gene Rho GTPase activating protein 8 Neighboring gene uncharacterized LOC105373062 Neighboring gene ribosomal protein L6 pseudogene 28 Neighboring gene uncharacterized LOC105373063 Neighboring gene Sharpr-MPRA regulatory region 3533 Neighboring gene uncharacterized LOC101927551 Neighboring gene Sharpr-MPRA regulatory region 5228 Neighboring gene NUP50 divergent transcript Neighboring gene uncharacterized LOC112267891 Neighboring gene nucleoporin 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PHD finger protein 21B
Names
PHD finger protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135862.3NP_001129334.1  PHD finger protein 21B isoform 2

    See identical proteins and their annotated locations for NP_001129334.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and uses an alternate, in-frame, acceptor splice site at one of the internal coding exons compared to transcript variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK092243, AL049760, BC012187, Z83838
    Consensus CDS
    CCDS46727.1
    UniProtKB/Swiss-Prot
    Q96EK2
    UniProtKB/TrEMBL
    A0A0S2Z665
    Conserved Domains (2) summary
    PRK10263
    Location:83267
    PRK10263; DNA translocase FtsK; Provisional
    cd15524
    Location:312354
    PHD_PHF21B; PHD finger found in PHD finger protein 21B (PHF21B)
  2. NM_001242450.2NP_001229379.1  PHD finger protein 21B isoform 3

    See identical proteins and their annotated locations for NP_001229379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon and uses an alternate, in-frame, acceptor splice site at one of the internal coding exons, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297317, BC012187, Z83838
    Consensus CDS
    CCDS56234.1
    UniProtKB/Swiss-Prot
    Q96EK2
    UniProtKB/TrEMBL
    B1AHC5
    Related
    ENSP00000379410.4, ENST00000396103.7
    Conserved Domains (2) summary
    cd15524
    Location:300342
    PHD_PHF21B; PHD finger found in PHD finger protein 21B (PHF21B)
    pfam11825
    Location:96155
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
  3. NM_001284296.2NP_001271225.1  PHD finger protein 21B isoform 4

    See identical proteins and their annotated locations for NP_001271225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream in-frame start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) is significantly shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091480, AK297317, BC012187, CN311600
    Consensus CDS
    CCDS63504.1
    UniProtKB/Swiss-Prot
    Q96EK2
    UniProtKB/TrEMBL
    B1AHC5
    Related
    ENSP00000385053.1, ENST00000403565.5
    Conserved Domains (1) summary
    cd15524
    Location:150192
    PHD_PHF21B; PHD finger found in PHD finger protein 21B (PHF21B)
  4. NM_138415.5NP_612424.1  PHD finger protein 21B isoform 1

    See identical proteins and their annotated locations for NP_612424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL049760, BC012187, Z83838
    Consensus CDS
    CCDS14061.1
    UniProtKB/Swiss-Prot
    Q96EK2
    UniProtKB/TrEMBL
    A0A0S2Z6R3
    Related
    ENSP00000324403.5, ENST00000313237.10
    Conserved Domains (2) summary
    cd15524
    Location:354396
    PHD_PHF21B; PHD finger found in PHD finger protein 21B (PHF21B)
    pfam11825
    Location:108193
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RNA

  1. NR_134535.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK092243, BC012187, KU178844, Z83838

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    44881162..45010005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724122.1XP_006724185.1  PHD finger protein 21B isoform X1

    See identical proteins and their annotated locations for XP_006724185.1

    UniProtKB/Swiss-Prot
    Q96EK2
    UniProtKB/TrEMBL
    A0A0S2Z665
    Related
    ENSP00000487086.1, ENST00000629843.2
    Conserved Domains (2) summary
    PRK10263
    Location:83267
    PRK10263; DNA translocase FtsK; Provisional
    cd15524
    Location:312354
    PHD_PHF21B; PHD finger found in PHD finger protein 21B (PHF21B)
  2. XM_011529855.1XP_011528157.1  PHD finger protein 21B isoform X2

    Conserved Domains (1) summary
    PRK10263
    Location:83306
    PRK10263; DNA translocase FtsK; Provisional
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