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Pzp PZP, alpha-2-macroglobulin like [ Mus musculus (house mouse) ]

Gene ID: 11287, updated on 12-Aug-2019

Summary

Official Symbol
Pzpprovided by MGI
Official Full Name
PZP, alpha-2-macroglobulin likeprovided by MGI
Primary source
MGI:MGI:87854
See related
Ensembl:ENSMUSG00000030359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1m; A2m; MAM; AI893533

Genomic context

See Pzp in Genome Data Viewer
Location:
6 F3; 6 63.02 cM
Exon count:
36
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128483567..128526720, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128433585..128476738, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene mitochondrial intermembrane space import and assembly protein 40 pseudogene Neighboring gene predicted pseudogene 8724

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
brain-derived neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryo implantation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pregnancy zone protein
Names
alpha 1 macroglobulin
alpha-2-M
alpha-2-macroglobulin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007376.4NP_031402.3  pregnancy zone protein precursor

    See identical proteins and their annotated locations for NP_031402.3

    Status: VALIDATED

    Source sequence(s)
    AC123060
    Consensus CDS
    CCDS39650.1
    Related
    ENSMUSP00000107760.1, ENSMUST00000112132.7
    Conserved Domains (6) summary
    cd02897
    Location:9701282
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:750840
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:127219
    A2M_N; MG2 domain
    pfam07677
    Location:13951482
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10221284
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:460605
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    128483567..128526720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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