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CYP4F8 cytochrome P450 family 4 subfamily F member 8 [ Homo sapiens (human) ]

Gene ID: 11283, updated on 8-Jul-2021

Summary

Official Symbol
CYP4F8provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 8provided by HGNC
Primary source
HGNC:HGNC:2648
See related
Ensembl:ENSG00000186526 MIM:611545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPF8; CYPIVF8
Summary
This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 2.3), skin (RPKM 0.2) and 2 other tissues See more
Orthologs
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Genomic context

See CYP4F8 in Genome Data Viewer
Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15615207..15630639)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15726029..15741449)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ribosomal protein L23a pseudogene 2 Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in icosanoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in prostaglandin metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 4F8
Names
cytochrome P450, family 4, subfamily F, polypeptide 8
cytochrome P450, subfamily IVF, polypeptide 8
flavoprotein-linked monooxygenase
microsomal monooxygenase
NP_009184.1
XP_024307108.1
XP_024307109.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008068.1 RefSeqGene

    Range
    5001..20422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007253.4NP_009184.1  cytochrome P450 4F8 precursor

    See identical proteins and their annotated locations for NP_009184.1

    Status: REVIEWED

    Source sequence(s)
    AD000685, AF133298, AI401776, DA871128, DA877298, DB329701
    Consensus CDS
    CCDS74303.1
    UniProtKB/Swiss-Prot
    P98187
    Related
    ENSP00000477567.1, ENST00000612078.5
    Conserved Domains (1) summary
    pfam00067
    Location:52504
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15615207..15630639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451341.1XP_024307109.1  cytochrome P450 4F8 isoform X2

    Related
    ENST00000441682.6
    Conserved Domains (1) summary
    pfam00067
    Location:52417
    p450; Cytochrome P450
  2. XM_024451340.1XP_024307108.1  cytochrome P450 4F8 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:52504
    p450; Cytochrome P450
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