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MGAT4B alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [ Homo sapiens (human) ]

Gene ID: 11282, updated on 7-Jun-2020

Summary

Official Symbol
MGAT4Bprovided by HGNC
Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Bprovided by HGNC
Primary source
HGNC:HGNC:7048
See related
Ensembl:ENSG00000161013 MIM:604561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNT-IV; GNT-IVB
Summary
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 64.0), duodenum (RPKM 63.6) and 24 other tissues See more
Orthologs

Genomic context

See MGAT4B in Genome Data Viewer
Location:
5q35.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (179797597..179806977, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179224597..179233952, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 pseudogene Neighboring gene leukotriene C4 synthase Neighboring gene microRNA 1229 Neighboring gene sequestosome 1 Neighboring gene Sharpr-MPRA regulatory region 15558 Neighboring gene MRN complex interacting protein Neighboring gene RN7SK pseudogene 150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
N-glycan processing TAS
Traceable Author Statement
more info
PubMed 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Names
N-acetylglucosaminyltransferase IVb
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb
alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
aminyltransferase
glcNAc-T IVb
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
NP_055090.1
NP_463459.1
XP_024310115.1
XP_024310116.1
XP_024310117.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014275.5NP_055090.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 1 precursor

    See identical proteins and their annotated locations for NP_055090.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AL537522, AY358984, BC051835
    Consensus CDS
    CCDS4448.1
    UniProtKB/Swiss-Prot
    Q9UQ53
    Related
    ENSP00000292591.7, ENST00000292591.12
    Conserved Domains (1) summary
    pfam04666
    Location:110387
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. NM_054013.3NP_463459.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 2

    See identical proteins and their annotated locations for NP_463459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and includes an additional in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (2) has a longer, distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK023137, AL162067
    Consensus CDS
    CCDS4449.1
    UniProtKB/Swiss-Prot
    Q9UQ53
    Related
    ENSP00000338487.5, ENST00000337755.9
    Conserved Domains (1) summary
    pfam04666
    Location:125402
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    179797597..179806977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454347.1XP_024310115.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X1

    Conserved Domains (1) summary
    pfam04666
    Location:110387
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. XM_024454348.1XP_024310116.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X2

    Conserved Domains (1) summary
    pfam04666
    Location:1242
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  3. XM_024454349.1XP_024310117.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform X3

    Related
    ENSP00000428906.1, ENST00000518778.5
    Conserved Domains (1) summary
    pfam04666
    Location:1242
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107298.1 Reference GRCh38.p13 PATCHES

    Range
    563170..572435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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