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KRT71 keratin 71 [ Homo sapiens (human) ]

Gene ID: 112802, updated on 7-Jun-2020

Summary

Official Symbol
KRT71provided by HGNC
Official Full Name
keratin 71provided by HGNC
Primary source
HGNC:HGNC:28927
See related
Ensembl:ENSG00000139648 MIM:608245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYPT13; K6IRS1; KRT6IRS; KRT6IRS1
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT71 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52543909..52553145, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52937693..52946931, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 6A Neighboring gene keratin 5 Neighboring gene keratin 74 Neighboring gene keratin 72 Neighboring gene keratin 73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119390, MGC119391

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 71
Names
CK-71
K71
cytokeratin-71
hK6irs
hK6irs1
keratin 6 irs
keratin 71, type II
type II inner root sheath-specific keratin-K6irs1
type-II keratin Kb34

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012426.1 RefSeqGene

    Range
    5003..14239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033448.3NP_258259.1  keratin, type II cytoskeletal 71

    See identical proteins and their annotated locations for NP_258259.1

    Status: REVIEWED

    Source sequence(s)
    AJ308599, AK122795
    Consensus CDS
    CCDS8831.1
    UniProtKB/Swiss-Prot
    Q3SY84
    Related
    ENSP00000267119.5, ENST00000267119.6
    Conserved Domains (3) summary
    pfam00038
    Location:129442
    Filament; Intermediate filament protein
    pfam16208
    Location:16126
    Keratin_2_head; Keratin type II head
    cl19885
    Location:198423
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52543909..52553145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018749.1XP_016874238.1  keratin, type II cytoskeletal 71 isoform X1

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