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IL17F interleukin 17F [ Homo sapiens (human) ]

Gene ID: 112744, updated on 2-Aug-2020

Summary

Official Symbol
IL17Fprovided by HGNC
Official Full Name
interleukin 17Fprovided by HGNC
Primary source
HGNC:HGNC:16404
See related
Ensembl:ENSG00000112116 MIM:606496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ML1; ML-1; CANDF6; IL-17F
Summary
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL17F in Genome Data Viewer
Location:
6p12.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52236681..52245689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52101484..52109298, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene uncharacterized LOC102724327 Neighboring gene solute carrier family 25 member 20 pseudogene 1 Neighboring gene minichromosome maintenance complex component 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Candidiasis, familial, 6
MedGen: C3151405 OMIM: 613956 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
cytokine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lymphotoxin A biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-17F
Names
cytokine ML-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031869.1 RefSeqGene

    Range
    5001..12815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_356

mRNA and Protein(s)

  1. NM_052872.4NP_443104.1  interleukin-17F precursor

    See identical proteins and their annotated locations for NP_443104.1

    Status: REVIEWED

    Source sequence(s)
    AF332389, BC070124
    Consensus CDS
    CCDS4938.1
    UniProtKB/Swiss-Prot
    Q96PD4
    Related
    ENSP00000337432.4, ENST00000336123.5
    Conserved Domains (1) summary
    pfam06083
    Location:77155
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52236681..52245689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514276.1XP_011512578.1  interleukin-17F isoform X1

    See identical proteins and their annotated locations for XP_011512578.1

    UniProtKB/Swiss-Prot
    Q96PD4
    Conserved Domains (1) summary
    pfam06083
    Location:77155
    IL17; Interleukin-17
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